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Introduction

  • Yinli WangEmail author
Chapter
Part of the Springer Theses book series (Springer Theses)

Abstract

N-Heterocyclic carbene (NHC) has been well known as one of the most powerful organocatalysts for promoting a wide range of transformations. In this chapter, the Umpolung ability of NHC to convert the electrophilic carbonyl group to the nucleophilic acyl anion or homoenolate intermediates will be discuss. Another unique character of NHC, generation of acyl azolium intermediates, will also be described here.

Keywords

N-heterocyclic carbene Umpolung Acylazolium 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Graduate School of Pharmaceutical SciencesKyoto UniversityKyotoJapan

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