NF-κB, IκB, and IKK: Integral Components of Immune System Signaling

  • Maria Carmen Mulero
  • Tom Huxford
  • Gourisankar GhoshEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1172)


The NF-κB (Nuclear Factor kappa B) transcription factor plays crucial roles in the regulation of numerous biological processes including development of the immune system, inflammation, and innate and adaptive immune responses. Control over the immune cell functions of NF-κB results from signaling through one of two different routes: the canonical and noncanonical NF-κB signaling pathways. Present at the end of both pathways are the proteins NF-κB, IκB, and the IκB kinase (IKK). These proteins work together to deliver the myriad outcomes that influence context-dependent transcriptional control in immune cells. In the present chapter, we review the structural information available on NF-κB, IκB, and IKK, the critical terminal components of the NF-κB signaling, in relation to their physiological function.


NF-κB (nuclear factor κB) IκB (inhibitor of NF-κB) IKK (IκB kinase) Signal transduction Transcription factor 



Research is funded by the National Institutes of Health Grant GM085490 to GG. Biochemistry research at SDSU is supported in part by the California Metabolic Research Foundation.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Maria Carmen Mulero
    • 1
  • Tom Huxford
    • 2
  • Gourisankar Ghosh
    • 1
    Email author
  1. 1.Department of Chemistry & BiochemistryUniversity of California San DiegoLa JollaUSA
  2. 2.Structural Biochemistry Laboratory, Department of Chemistry & BiochemistrySan Diego State UniversitySan DiegoUSA

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