Simultaneous EEG-fMRI combines the advantages of high temporal resolution of EEG with high spatial resolution of fMRI. In addition, it is a noninvasive technique for the study of human brain function. However, it remains many challenges such as the low signal-to-noise ratio, poor individual comfort, and difficulty in data analysis. In this chapter, we first introduce the hardware of simultaneous EEG-fMRI system. Then a review about the advance of this technique is given, including the EEG artifacts correction, the EEG-fMRI data fusion method, and the application of EEG-fMRI. Specifically, we provide a systematic classification for the fMRI-constrained EEG and the EEG-informed fMRI from simple to complex level. Then we provide program practice for the EEG artifacts correction, which may contribute to the widespread application of this new technique. Finally, we discuss the prospects of simultaneous EEG-fMRI for future research.
KeywordsEEG-fMRI Fusion EEG artifacts correction fMRI-constrained EEG EEG-informed fMRI
- Goldman RI, Wei CY, Philiastides MG, Gerson AD, Friedman D, Brown TR, Sajda P. Single-trial discrimination for integrating simultaneous EEG and fMRI: identifying cortical areas contributing to trial-to-trial variability in the auditory oddball task. Neuroimage. 2009;47:136–47.PubMedPubMedCentralCrossRefGoogle Scholar
- Nunez P. Neocortical dynamics and human EEG rhythms. Oxford: Oxford University Press; 1995.Google Scholar
- Schabus M, Dang-Vu TT, Albouy G, Balteau E, Boly M, Carrier J, Darsaud A, Degueldre C, Desseilles M, Gais S, Phillips C, Rauchs G, Schnakers C, Sterpenich V, Vandewalle G, Luxen A, Maquet P. Hemodynamic cerebral correlates of sleep spindles during human non-rapid eye movement sleep. Proc Natl Acad Sci. 2007;104:13164–9.PubMedCrossRefPubMedCentralGoogle Scholar
- Trujillo-Barreto N, Martinez-Montes E, Melie-Garcia L, Valdes-Sosa P. A symmetrical Bayesian model for fMRI and EEG/MEG neuroimage fusion. Int J Bioelectromag. 2001;3:1.Google Scholar
- van der Meer JN, Pampel A, Van Someren EJW, Ramautar JR, van der Werf YD, Gomez-Herrero G, Lepsien J, Hellrung L, Hinrichs H, Moller HE, Walter M. Carbon-wire loop based artifact correction outperforms post-processing EEG/fMRI corrections--a validation of a real-time simultaneous EEG/fMRI correction method. Neuroimage. 2016;125:880–94.PubMedCrossRefGoogle Scholar
- Yu Q, Erhardt EB, Sui J, Du Y, He H, Hjelm D, Cetin MS, Rachakonda S, Miller RL, Pearlson G, Calhoun VD. Assessing dynamic brain graphs of time-varying connectivity in fMRI data: application to healthy controls and patients with schizophrenia. Neuroimage. 2015;107:345–55.PubMedCrossRefGoogle Scholar