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Urine pp 41-47 | Cite as

Posttranslation Modifications of Human Urine

  • Weiwei Qin
  • Mingshan Wang
Chapter

Abstract

Urine is a promising resource for potential biomarkers. Assessment of the posttranslational modifications (PTMs) is critical when studying protein function/activity, folding, and molecular interactions in relation to disease. Most of the researches on urinary proteome concentrate on the changes of expressional level of proteins. However, many important biological processes are controlled not only by the relative abundance of proteins but also by PTMs. Modification-specific enrichment techniques, coupled with high-resolution mass spectrometry, have greatly enhanced the ability to identify confident PTMs in urine. Enrichment or visualization of proteins with specific posttranslational modifications provides a method for sampling the urinary proteome and reducing sample complexity.

Keywords

Posttranslational modifications Urine Glycosylation Phosphorylation Acetylation 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Weiwei Qin
    • 1
  • Mingshan Wang
    • 1
  1. 1.Department of Anesthesiology, Qingdao Municipal HospitalQingdao UniversityQingdaoChina

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