Urine pp 9-24 | Cite as

Human Urine Proteome: A Powerful Source for Clinical Research

  • Xiaolian Xiao
  • Lili Zou
  • Wei Sun


As noninvasive and easily available biological fluid, urine is becoming an ideal sample for clinical disease biomarker study. In recent years, researchers endeavored in profiling urinary proteome and discovering potential disease biomarkers. However, there are still many challenges in the studies of urinary proteome due to the complexity of urine. In this article, we review current status of urinary sample preparation, including collection, storage, and extraction of urinary proteins, and the overall urinary proteome analysis so far, which may be helpful for urinary proteome analysis.


Urinary proteome Mass spectrometry Preparation and storage 



A part of this chapter is reused with permission from our previous published book chapter, Zou L., Sun W. (2015) Human Urine Proteome: A Powerful Source for Clinical Research. In: Gao Y. (eds) Urine Proteomics in Kidney Disease Biomarker Discovery. Advances in Experimental Medicine and Biology, vol 845. Springer, Dordrecht.

Conflict of Interest

The authors have declared no conflict of interest.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Xiaolian Xiao
    • 1
  • Lili Zou
    • 1
  • Wei Sun
    • 1
  1. 1.Core Facility of Instrument, Institute of Basic Medical SciencesChinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical CollegeBeijingChina

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