Urine pp 167-188 | Cite as

The Application of Urinary Proteomics in Early Detection of Digestive Diseases

  • Linpei Zhang
  • Fanshuang Zhang
  • Weiwei Qin


Digestive diseases are disorders of the digestive organs, which may range from benign to serious. There is an inherent difficulty in diagnosis and treatment of various chronic digestive diseases; thus noninvasive early biomarkers are desperately needed. Without homeostasis mechanisms, urine is an ideal biomarker source that can reflect the early changes of disease theoretically. In this section, we will introduce the new studies of the urine proteome in rat models of three digestive diseases including liver fibrosis, chronic pancreatitis and inflammatory bowel disease. Many potential biomarkers were found earlier than clinical symptom and significant pathological changes that may provide important clues for the early detection of these diseases. We think urine proteome has a broad application prospect in the early diagnosis, treatment, monitoring, and prognosis of digestive diseases.


Urinary proteomics Liver fibrosis Chronic pancreatitis Inflammatory bowel disease Animal models 



This chapter is based on published articles:

  1. 1.

    Zhang F, Ni Y, Yuan Y, Yin W, Gao Y. Early urinary candidate biomarker discovery in a rat thioacetamide-induced liver fibrosis model. Science China Life Sciences. 2018; 61(11):1369–1381.

  2. 2.

    Zhang L, Li Y, Gao Y. Early changes in the urine proteome in a diethyldithiocarbamate-induced chronic pancreatitis rat model. J Proteomics. 2018;186:8–14.

  3. 3.

    Qin W, Li L, Wang T, Huang H, Gao Y. Urine proteome changes in a TNBS-induced colitis rat model. Proteomics Clin Appl. 2019; e1800100.



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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Linpei Zhang
    • 1
  • Fanshuang Zhang
    • 2
  • Weiwei Qin
    • 3
  1. 1.School of Life SciencesBeijing Normal UniversityBeijingChina
  2. 2.Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  3. 3.Department of Anesthesiology, Qingdao Municipal HospitalQingdao UniversityQingdaoChina

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