Mechanisms of Action of Phenolic Phytochemicals in Diabetes Management

  • Muddasarul Hoda
  • Shanmugam Hemaiswarya
  • Mukesh Doble


Phenolic phytochemicals have potential therapeutic efficacy against diabetes mellitus. Since diabetes mellitus is a multifactorial disease, it becomes imperative to find a therapeutic option which could be multifactorial in its mechanism of action. Phenolic phytochemicals have the ability to modulate metabolic and signaling pathways at various levels including gene expressions, epigenetic regulation, protein expressions, enzyme activities, etc. All of these therapeutic mechanisms may be extremely complex and overlapping; hence, in this chapter we intend to delineate molecular pathways of antidiabetic effects of phenolic phytochemicals, and simply understand molecular mechanisms of action underlying therapeutic potential of phenolic phytochemicals against diabetes mellitus.


Diabetes-related cell signaling Diabetes regulatory genes Glucose homeostasis Epigenetics-regulatory enzymes Enzymes activity Phenolic phytochemicals 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Muddasarul Hoda
    • 1
    • 2
  • Shanmugam Hemaiswarya
    • 1
  • Mukesh Doble
    • 1
  1. 1.Department of BiotechnologyIndian Institute of Technology MadrasChennaiIndia
  2. 2.Department of Biological SciencesAliah UniversityKolkataIndia

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