Fluoride Nanoparticles for Biomedical Applications

  • M. S. Pudovkin
  • R. M. Rakhmatullin


This chapter is devoted to the use of fluoride nanoparticles in biomedicine. We overview the use of the fluoride nanoparticles in important areas such as thermometry of a single cell, hyperthermia, photodynamic therapy, caries prevention, antioxidant therapy, magnetic resonance imaging, and bioimaging. The toxicity of some fluoride nanoparticles is also discussed. The main conclusion is that rare earth doped fluoride nanoparticles (especially rare earth doped LnF3 (Ln = La, Ce), NaF4, NaGdF4) successfully proved its efficiency in the above-mentioned areas toward eukaryotic cells and small animals. It should be mentioned that LnF3 (Ln = La, Ce) and NaGdF4 nanoparticles demonstrate low toxicity in vitro and in vivo.



The works was supported by the subsidy allocated to KFU for the state assignment in the sphere of scientific activities [3.1156.2017/4.6] and [3.5835.2017/6.7]. Maksim Pudovkin was supported by the research grant of Kazan Federal University.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • M. S. Pudovkin
    • 1
  • R. M. Rakhmatullin
    • 1
  1. 1.Kazan Federal UniversityKazanRussia

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