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Myocardial Oxidative Stress and Metabolic Diseases

  • Hassan I. H. El-SayyadEmail author
Chapter

Abstract

Aging, diabetes, obesity, atherosclerosis, hypertension, and dyslipidemia shared similar manifestations of cardiomyopathy. This disease is characterized by pathological, cytological, and molecular alterations of both cardiomyocytes and endothelial cells. The disease altered the cytoplasmic organelle structure and function such as mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. These involved dramatic changes of protein synthesis in endoplasmic reticulum, calcium storage in mitochondria, autophagy in lysosomes, and lipid metabolism in Golgi complex. Enhanced lipid peroxidation, oxidative stress, and release of free oxygen species are the main contributing factors of cell damage and cell death. This review summarized the concept of oxidative stress in cardiomyocytes and role of each cytoplasmic organelle in its development during progress of the disease.

Keywords

Oxidative stress Myocardium Aging Diabetes Obesity Cytoplasmic organelles 

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Zoology, Faculty of ScienceMansoura UniversityMansouraEgypt

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