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Modulation of miRNA in Oxidative Stress-Induced Cardiac Remodeling

  • Sudhiranjan GuptaEmail author
Chapter

Abstract

Cardiac remodeling is the pathological ramification of myocardium resulting into various cardiac diseases. Oxidative stress represents a self-perpetuating mechanism by producing excess reactive oxygen species (ROS) and plays a critical role in cardiac remodeling. A redox state that maintains the homeostatic balance in the cell is critical in cardiac remodeling. A misbalance of redox state triggers cellular damage and promoting adverse signaling pathways leading to apoptosis. MicroRNAs (miRNAs) are short, 19–21 nucleotides, endogenous noncoding RNAs modulate gene regulation, elicits a vital role in cardiac remodeling including cardiac hypertrophy, fibrosis, myocardial injury and arrythmia via multiple mechanisms. Recent studies indicated that miRNAs are influencing the generation of ROS and modulate antioxidant defense mechanism by regulating antioxidative enzymes and are termed as “redoximiRs.” Here, I review the current progress and the mechanisms by which “redoximiRs” regulate cardiac remodeling.

Keywords

Cardiac remodeling miRNA Oxidative stress 

Notes

Acknowledgments

The work was partly supported by funds from American Heart Association: Grant-in-Aid (17GRNT33670897) to S Gupta. The material is the result of work supported with resources and the use of facilities at the Central Texas Veterans Affairs Health Care System, Temple, Texas; VISN 17 Center of Excellence on Returning War Veterans, Waco, Texas, USA.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Central Texas Veterans Health Care SystemTempleUSA
  2. 2.VISN 17 Center of Excellence on Returning War VeteransDoris Miller VA Medical CenterWacoUSA
  3. 3.Department of BiologyBaylor UniversityWacoUSA

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