Nanobiomaterials for Bone Tissue Engineering

  • Baboucarr Lowe
  • Fernando Guastaldi
  • Max-Laurin Müller
  • Fredrick Gootkind
  • Maria J. Troulis
  • Qingsong YeEmail author
Part of the Springer Series in Biomaterials Science and Engineering book series (SSBSE, volume 14)


Biomaterials with functional properties are used to fabricate scaffolds for bone tissue engineering. Several of these materials can be derived from nature, processed and transformed into regenerative scaffolds and/or artificial matrices for applications in bone tissue repair or regeneration. In this chapter, we discuss the basic biology of bone development and the utilization of chitosan, hydroxyapatite and diatoms for BTE. The regenerative properties of Chitosan are desirable due to its close proximity with glycosaminoglycan—an extracellular matrix polysaccharide, which interacts with collagen fibers. Nano-hydroxyapatite is an inorganic component of natural bone matrix with osteoinductive properties. Diatoms are important source of biogenic silica and their high surface area, as well as nanoscopic pore structure make them desirable for delivery of biomolecules and reinforcing structural functions of three-dimensional scaffold matrices. Additionally, we discussed the methods used to fabricate the scaffolds for bone repair.


Nanobiomaterials Bone tissue engineering Chitosan Nano-hydroxyapatite Diatoms 



This project in part was supported by the Australian Government Research Training Program Scholarship, The University of Queensland; The UQDVCR (610709 to Qingsong Ye); MGH-OMFS Education Research Fund; The Lynn Foundation; The Jean Foundation; The Walter C. Guralnick Fund.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Baboucarr Lowe
    • 1
    • 2
  • Fernando Guastaldi
    • 2
  • Max-Laurin Müller
    • 2
  • Fredrick Gootkind
    • 2
  • Maria J. Troulis
    • 2
  • Qingsong Ye
    • 1
    Email author
  1. 1.School of DentistryThe University of Queensland, HerstonBrisbaneAustralia
  2. 2.Department of Oral and Maxillofacial SurgeryMassachusetts General Hospital and Harvard School of Dental Medicine, Skeletal Biology Research CentreBostonUSA

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