Marine Derived Biomaterials for Bone Regeneration and Tissue Engineering: Learning from Nature

  • Besim Ben-NissanEmail author
  • Andy H. Choi
  • David W. Green
Part of the Springer Series in Biomaterials Science and Engineering book series (SSBSE, volume 14)


Marine structures, biogenic materials, and biomimetic approaches applied to the fabrication of advanced biomaterials and implants are used to address the shortcomings of existing scaffold designs that are biologically un-responsive throughout the regeneration process and lack necessary versatility. Bioactive ceramics converted from biostructures or natural marine-based materials such as corals, sea urchin, sponges and shells are being designed into functional scaffolds that can adapt and evolve to changing environment during regeneration process. They can regulate cell responses at nanostructured surfaces, and as modules for self-assembling by the patient’s own cells and as smart devices that possess tissue specific homing capabilities. These natural structures can be converted to bioactive ceramics such as hydroxyapatite to assist osseointegration. This chapter covers biomimicry, evolution of marine structures, and their specific use and current research on natural materials such as coral, sponge, sea urchin, sponge nacre, and foraminifera as models and raw materials for bioactive bone scaffolding materials and tissue engineering.


Marine structures Hydroxyapatite Bioactive Biogenic Biomimetics Coral Nacre Bone grafts Scaffolding 



I would like to sincerely thank Dr. David W. Green, Dr. Innocent Macha, Dr. Jimmy Hu, Prof. Faik Oktar and Associate Profs. Sophie Cazelbou and Sibel Akyol and a large number of our students and postdocs that contributed to research in marine materials and their application in the medical field.


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Copyright information

© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

Authors and Affiliations

  • Besim Ben-Nissan
    • 1
    Email author
  • Andy H. Choi
    • 1
  • David W. Green
    • 1
  1. 1.School of Life Sciences, Biomaterials and Advanced Tissue EngineeringUniversity of Technology SydneySydneyAustralia

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