Dynamic Protein Allosteric Regulation and Disease

  • Ruth NussinovEmail author
  • Chung-Jung Tsai
  • Hyunbum Jang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1163)


Allostery is largely associated with conformational and functional transitions in individual proteins. All dynamic proteins are allosteric. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states. In this section, we will illuminate how allostery can control physiological activities and cause disease, aiming to increase the awareness of the linkage between disease symptoms on the cellular level and specific aberrant allosteric actions on the molecular level.


Cell organization Cell signaling Signaling pathways Signal transduction Cell structure Signaling modules Diffusion 



This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract number HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US government. This research was supported (in part) by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research.


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer ResearchNational Cancer InstituteFrederickUSA
  2. 2.Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

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