New Paradigm in Degradation of Lignocellulosic Biomass and Discovery of Novel Microbial Strains

  • Rohit Rai
  • Dhruv Agrawal
  • B. S. Chadha


Microbial degradation of lignocellulosic biomass (LCB) is of great human interest as it results in the production of numerous value-added products. 2G ethanol is an important lignocellulosics-based product that offers a long-term biotechnological solution to the depleting crude oil reserves without competing with food resources. The efficient degradation of LCB requires synergistic action of an array of microbial enzymes that include modular and non-modular glycosyl hydrolases (endoglucanase, exoglucanase, β-glucosidase, endoxylanase, β-xylosidase, α-arabinofuranosidase, α-glucuronidase, α-galactosidases and β-mannosidases), carbohydrate esterases (CE proteins) and other auxiliary enzymes (LPMOs, CDH and laccases). The genomics and proteomics studies have suggested a variety of culturable and non-culturable lignocellulolytic microorganisms inhabiting diverse ecological niches such as decaying plant materials, soil, compost piles, rumens, forest waste piles, wood processing plants, methanogenic sludge and surface of seashore. Among the rich microbial diversity, fungi are known for their ability to produce copious amounts of these lignocellulolytic enzymes. The wild-type fungal strains (with low specific activities) are subjected to several strain improvement strategies employing cyclic mutagenesis, recombinant technologies and other molecular techniques targeting regulatory elements to enhance their enzyme titres, specific activities and catalytic/hydrolytic efficiencies. The cellulase-/hemicellulase-rich preparations produced by growing developed strains on inexpensive agro-residues as carbon sources (under SSF and/or SmF) find potential applications in biorefineries, paper and pulp industry, animal feed, food and beverages industry and textile and detergent industry, making global business of USD 800 million per year.


Glycosyl hydrolases Auxiliary enzymes Recombinant proteins Mutagenesis Protoplast transformation Hydrolysis 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Rohit Rai
    • 1
  • Dhruv Agrawal
    • 1
  • B. S. Chadha
    • 1
  1. 1.Department of MicrobiologyGuru Nanak Dev UniversityAmritsarIndia

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