Role of Chemical Exposure in Oxidant-Mediated Lung Diseases
The population-based epidemiological studies indicate a clear and close association between exposure to oxidant pollutants and commencement of cardiopulmonary diseases. The inhaled oxidants induce an avalanche of free radical production that affects several pathophysiological processes characterized by decrease in respiratory capacity, airway inflammation, etc. The pollutant exposure response shows variation in an age-dependent individualistic way. This review addresses different sources of pollutants, their contribution to reactive oxygen species (ROS) production, the cell- and tissue-specific effects of ROS, modulation of signalling cascades and onset of lung diseases.
SKN is thankful to the Department of Biotechnology, Ministry of Science and Technology, Government of India, for funding, and the Bioinformatics Centre (BIF), NEHU, Tura Campus, for providing the infrastructure.
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