Oxidative Stress and Immune Regulation During Chronic Respiratory Diseases
Chronic respiratory disease is one of the leading cause of death worldwide. A group of chronic diseases causing abnormalities in lung airway and other architectures of lungs can be defined as chronic respiratory diseases. Asthma, chronic obstructive pulmonary disease (COPD), lung fibrosis, and lung cancer are included in chronic respiratory diseases. The lungs contain different enzymatic and non-enzymatic anti-oxidants that buffer numerous pro-oxidant infiltrations or generations in lungs. Imbalance in pro- and anti-oxidants cause oxidative stress that is known to be associated with the pathogenesis of different chronic respiratory diseases. Both innate and adaptive immune components have positive and negative regulatory effects on different chronic lung diseases. Lung inflammation is an important phenomenon of all respiratory diseases. Oxidative stress has been found to propagate inflammation. Thus, oxidative stress is linked with immune regulation and significantly associated with the pathogenesis of chronic respiratory disease.
KeywordsChronic respiratory disease Asthma Chronic obstructive pulmonary disease (COPD) Pulmonary fibrosis Oxidative stress Immune regulation
The authors are thankful to the Department of Zoology, University of Calcutta for support and research scholars of the Immunology Laboratory for their generous help and support for completing this research work.
The authors are thankful to the University Grant Commission (UGC) for fellowship support of Soumya Chatterjee (802/ CSIR-UGC NET DEC 2016) and the Council of Scientific and Industrial Support (CSIR) for funding support [No. 27(0323)/17/EMR-II, dated 12/04/2017], Government of India.
Declaration of Conflict of Interest
The authors declare there is no conflict of interest.
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