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Effects of Freezing-Thawing Cycles on Mechanical Strength of Poly (Vinyl Alcohol) Hydrogels

  • Sen Wang
  • Heng Li
  • ZhiMing Qi
  • MengHong Yin
  • ChengWei Wu
  • Wei ZhangEmail author
Conference paper
Part of the Lecture Notes in Mechanical Engineering book series (LNME)

Abstract

Poly (vinyl alcohol) (PVA) hydrogels are widely used in biomimetic cartilage materials for its good biocompatibility and super shock absorbing properties. However, the small pore size, in general, a few micrometers, of pure PVA hydrogels prepared through freezing-thawing method can not provide the suitable microenvironment for the proliferation of chondrocytes, restricting the application of hydrogels in artificial cartilage. In order to solve this barrier, here, agarose is introduced as porogen to prepare the macroporous PVA hydrogels through freezing-thawing method. The obtained PVA hydrogel have the pore size of 20–200 μm, and macropores have good connectivity. The mechanical properties of the macroporous hydrogels are tested using uniaxial compression and tension experiments and the results show that the mechanical properties of macroporous PVA hydrogels are dependent on the preparation parameters, e.g. the duration of freezing, number of freezing-thawing cycles and the temperature of thawing. After optimization, the mechanical properties of the macroporous PVA hydrogels are closer to those of natural articular cartilage and the obtained hydrogels may be used as the artificial replacement materials.

Keywords

Mechanical strength Smart materials Poly (vinyl alcohol) Hydrogel Cartilage 

Notes

Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (11772086, 51775541, 11572080, 51811530309), the Natural Science Foundation of Liaoning Province (201800935), and the Fundamental Research Funds for the Central Universities in China (DUT18ZD302).

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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Sen Wang
    • 1
  • Heng Li
    • 1
  • ZhiMing Qi
    • 2
  • MengHong Yin
    • 2
  • ChengWei Wu
    • 1
  • Wei Zhang
    • 1
    Email author
  1. 1.State Key Laboratory of Structure Analysis for Industrial Equipment, Department of Engineering MechanicsDalian University of TechnologyDalianChina
  2. 2.Department of Sports MedicineDalian Municipal Central HospitalDalianChina

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