Regulating Inflammatory Cytokines in the Diabetic Heart

  • Santosh K. Yadav
  • Tyler N. Kambis
  • Paras K. MishraEmail author


Diabetes mellitus (DM) is an independent cause of cardiomyopathy. It increases the risk of heart failure and mortality, which is not alleviated by intensive glycemic control in clinical trials. Since diabetic cardiomyopathy (DMCM) can not be cured and glycemic control has limited effects on it, novel therapeutic strategies for DMCM are warranted. One of the hallmarks of the DM heart is increased inflammation that contributes to pyroptosis, an inflamamtory cell death mechanism. Pyroptosis results in release of interleukin-1β (IL-1β) and IL-18 inflamamtory cytokines that further increase inflamamtion. Thus, a vicious cycle of inflammation-induced inflammatory cell death continues leading to DMCM. Inflammation also promotes adverse cardiac remodeling leading to DMCM. Thus, the regulation of DM-induced inflammatory cytokines is important. This chapter focuses on the key regulators of inflammatory cytokines in the DM heart and their potential roles as atherapeutic target for DMCM.


Diabetes mellitus Heart failure Inflammation Cardiomyopathy 



This work is supported, in parts, by the National Institutes of Health grants HL-113281 and HL-116205 to Paras K. Mishra.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Santosh K. Yadav
    • 1
  • Tyler N. Kambis
    • 1
  • Paras K. Mishra
    • 1
    • 2
    Email author
  1. 1.Department of Cellular and Integrative PhysiologyUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Department of AnesthesiologyUniversity of Nebraska Medical CenterOmahaUSA

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