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Taurine 11 pp 1069-1081 | Cite as

Scallop Extracts Inhibited LPS-Induced Inflammation by Suppressing MAPK and NF-κB Activation in RAW264.7 Macrophages

  • Xin Dong
  • Yon-Suk Kim
  • Eun-Kyung Kim
  • Woen-Bin Shin
  • Jin-Su Park
  • Su-Jin Kim
  • Eun-Ae Go
  • Pyo-Jam Park
  • Sang-Chul KwonEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Scallops belong to cosmopolitan family of bivalves which are found in any oceans. They are one of the most important marine fishery resources in the world. The shell, meat and pearl layer have a high utilization value and a lot of scallops are eaten as food. In this study, we established anti-inflammatory effect of Scallops water extract in lipopolysaccharide (LPS) stimulated RAW 264.7 mononuclear macrophage. Our results indicated that Scallop water extract effectively reduced the synthesis of nitric oxide (NO). In addition, Scallop water extract suppressed the reactive oxygen species (ROS) generation and the expression of IL-6 and TNF-α. Further investigation indicated that anti-inflammatory effect of Scallop water extract via suppressing downregulation of MAPK (JNK, p38 and ERK) and NF-κB signaling.

Keywords

Scallop extracts Inflammation MAPK and NF-κB signaling Macrophages 

Notes

Acknowledgments

This chapter was modified from the paper published by our group in Food Science and Biotechnology (Kim et al. 2017; 26(6):1633–1640). The related contents are re-used with the permission.

Conflict of Interest

The authors declare that there are no conflicts of interest.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Xin Dong
    • 1
  • Yon-Suk Kim
    • 2
  • Eun-Kyung Kim
    • 3
  • Woen-Bin Shin
    • 1
  • Jin-Su Park
    • 1
  • Su-Jin Kim
    • 1
  • Eun-Ae Go
    • 1
  • Pyo-Jam Park
    • 1
    • 4
  • Sang-Chul Kwon
    • 5
    Email author
  1. 1.Department of Applied Life ScienceKonkuk UniversityChungjuRepublic of Korea
  2. 2.BK21plus Glocal Education Program of Nutraceuticals DevelopmentKonkuk UniversityChungjuRepublic of Korea
  3. 3.Division of Food Bio ScienceKonkuk UniversityChungjuRepublic of Korea
  4. 4.Department of Integrated BiosciencesKonkuk UniversityChungjuRepublic of Korea
  5. 5.Department of Food Science and TechnologyKorea National University of TransportationJeungpyeongRepublic of Korea

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