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Taurine 11 pp 1057-1067 | Cite as

Ribose-Taurine Suppresses Inflammation Through NF-κB Regulation in Activated RAW 264.7 Macrophages

  • Hwan Lee
  • Dong-Sung Lee
  • Kyung Ja Chang
  • Sung Hoon Kim
  • Sun Hee Cheong
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Ribose-taurine (Rib-T) suppressed the generation of inflammatory mediators and cytokines, such as nitric oxide (NO) and prostaglandin E2 (PGE2) through the inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β induced by LPS was effectively blocked by Rib-T. Moreover, the anti-inflammatory actions of Rib-T were involved in its inhibitory effects against the nuclear translocation of nuclear factor-kappa B (NF-κB) p65, and NF-κB DNA-binding activity. These results suggest that the anti-inflammatory action of Rib-T is associated with NF-κB regulation.

Keywords

Ribose-taurine Inflammatory NF-κB activation RAW 264.7 macrophage 

Abbreviations

Rib-T

ribose-taurine

LPS

lipopolysaccharide

iNOS

inducible nitric oxide synthase

NO

nitric oxide

COX-2

cyclooxygenase-2

PGE2

prostaglandin E2

IL-6

interleukin-6

IL-1β

interleukin-1β

TNF-α

tumor necrosis factor-α

NF-κB

nuclear factor-kappa B

Notes

Acknowledgements

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1B01006822).

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Hwan Lee
    • 1
  • Dong-Sung Lee
    • 1
  • Kyung Ja Chang
    • 2
  • Sung Hoon Kim
    • 3
  • Sun Hee Cheong
    • 4
  1. 1.College of PharmacyChosun UniversityDong-gu, GwangjuRepublic of Korea
  2. 2.Department of Food and NutritionInha UniversityIncheonRepublic of Korea
  3. 3.Department of ChemistryKonkuk UniversitySeoulRepublic of Korea
  4. 4.Department of Marine Bio-Food SciencesChonnam National UniversityYeosuRepublic of Korea

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