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Taurine 11 pp 989-999 | Cite as

Anti-inflammatory Action of Glucose-Taurine Reduced by Inhibiting NF-κB Activation in LPS-Activated RAW264.7 Macrophages

  • Hwan Lee
  • Dong-Sung Lee
  • Kyung Ja Chang
  • Sung Hoon Kim
  • Sun Hee Cheong
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

In the present study, we investigated the regulation of inflammatory effects by glucose-taurine reduced (G-T-R), a taurine-carbohydrate derivative, on lipopolysaccharide (LPS)-induced RAW264.7 macrophages. The anti-inflammatory action of G-T-R revealed that this derivative markedly inhibited the nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW264.7 macrophages induced by LPS. Suppression of NO and PGE2 production was involved in the inhibitory action by G-T-R on the inducible nitric oxide synthase and cyclooxygenase-2 proteins expression. G-T-R decreased the production of a variety of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, and interleukin-6. Moreover, G-T-R effectively suppressed the nuclear factor-kappa B (NF-κB) activation in LPS-stimulated RAW264.7 macrophages according to evaluation of the molecular inflammatory mechanisms. Thus, we suggest that G-T-R modulates several inflammatory pathways mediated by NF-κB activation, demonstrating its potential or preventing and treating inflammatory conditions.

Keywords

Glucose-taurine reduced Lipopolysaccharide Anti-inflammatory Nuclear factor-κB activation RAW264.7 macrophages 

Abbreviations

G-T-R

glucose-taurine reduced

LPS

lipopolysaccharide

iNOS

inducible nitric oxide synthase

NO

nitric oxide

COX-2

cyclooxygenase-2

PGE2

prostaglandin E2

IL-6

interleukin-6

IL-1β

interleukin-1β

TNF-α

necrosis factor-α

NF-κB

nuclear factor-kappa B

Notes

Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. NRF-2018R1C1B6001913).

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Hwan Lee
    • 1
  • Dong-Sung Lee
    • 1
  • Kyung Ja Chang
    • 2
  • Sung Hoon Kim
    • 3
  • Sun Hee Cheong
    • 4
  1. 1.College of PharmacyChosun UniversityDong-gu, GwangjuRepublic of Korea
  2. 2.Department of Food and NutritionInha UniversityIncheonRepublic of Korea
  3. 3.Department of ChemistryKonkuk UniversitySeoulRepublic of Korea
  4. 4.Department of Marine Bio-Food SciencesChonnam National UniversityYeosuRepublic of Korea

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