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Taurine 11 pp 875-887 | Cite as

Protective Effect of Taurine on Apoptosis of Spinal Cord Cells in Diabetic Neuropathy Rats

  • Inam-u-llah
  • Xiaoxia Shi
  • Mengren Zhang
  • Kaixin Li
  • Pingan Wu
  • Raheel Suleman
  • Muhammad Shahbaz
  • Ayaz Taj
  • Fengyuan Piao
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Diabetes mellitus (DM) is a condition characterized by chronic hyperglycemia, which leads to diabetic neuropathy and apoptosis in the spinal cord. Taurine has been found to ameliorate the diabetic neuropathy and control apoptosis in various tissues. However, there are few reports that discuss the direct relationship between spinal cord and anti-apoptotic effect of taurine. In this study, DM was induced in male SD rats with STZ @ 25 mg/Kg of body weight in combination with high fat diet. After 2 weeks, they were divided into four groups as DM: diabetic rats, T1 (0.5%), T2 (1%) and T3 (2%) taurine solution, while control group was non-diabetic rats (no treatment). The results showed that DM increased apoptosis, decreased phosphorylated Akt and Bad. DM decreased expression of Bcl-2 and increased the Bax. Moreover, the release of cytochrome c into cytosol was increased in DM and activation of caspase-3 was also increased. However, taurine reversed all these abnormal changes in a dose dependent manner. Our results suggested the involvement of Akt/Bad signaling pathway and mitochondrial apoptosis pathway in protective effect of taurine against apoptosis in the spinal cord of diabetic rats. Therefore, taurine may be a potential medicine against diabetic neuropathy by controlling apoptosis.

Keywords

Diabetic neuropathy Spinal cord Apoptosis Taurine Anti-apoptosis 

Notes

Conflict of Interest

It is declared that there is no conflict of interest among the authors.

Research Subjects

It is declared that no animal was harmed or hurt except according to ethics.

Informed Consent

It is declared that this manuscript is submitted after consent from all authors and all authors are aware of this submission.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Inam-u-llah
    • 1
  • Xiaoxia Shi
    • 1
  • Mengren Zhang
    • 1
  • Kaixin Li
    • 1
  • Pingan Wu
    • 1
  • Raheel Suleman
    • 2
  • Muhammad Shahbaz
    • 3
  • Ayaz Taj
    • 4
  • Fengyuan Piao
    • 1
  1. 1.Department of Occupational and Environmental HealthDalian Medical UniversityDalianChina
  2. 2.Institute of Food Science and Technology, Chinese Academy of Agricultural ScienceBeijingChina
  3. 3.Department of Food Science and TechnologyMuhammad Nawaz Sharif University of AgricultureMultanPakistan
  4. 4.Department of Biochemistry and Molecular BiologyDalian Medical UniversityDalianChina

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