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Taurine 11 pp 739-746 | Cite as

Protective Effect of Taurine on Paraquat-Induced Lung Epithelial Cell Injury

  • Shuangxing Li
  • Jinhua Wang
  • Bin Kai Wei
  • Guangtao Dong
  • Xiujie Wang
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

The herbicide Paraquat induce oxidative stress-mediated lung injury. Taurine is a well-known antioxidant. This study was designed to explore the effect of taurine on paraquat-induced injury and its related mechanism in A549 cells. The cells were pretreated with various concentrations of taurine for 30 min prior to paraquat exposure. 24 h later, cell viability was examined by the MTT assay. The level of glutathione (GSH) and the activity of glutathione peroxidase (GPx) were analyzed. The results show that taurine treatment significantly attenuates the decrease in cell viability mediated by paraquat in A549 cells. Taurine also reversed paraquat-induced disturbances in GSH content and GPx activity. Taurine exerts protection against paraquat-mediated A549 cell toxicity likely through modulation of oxidative stress.

Keywords

Taurine Paraquat Oxidative stress Lung injury 

Abbreviations

GSH

glutathione

GPx

Glutathione peroxidase

DMSO

dimethyl sulfoxide

DTNB

5,5′-dithiobis-2-nitrobenzoic acid

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Shuangxing Li
    • 1
  • Jinhua Wang
    • 2
  • Bin Kai Wei
    • 2
  • Guangtao Dong
    • 1
  • Xiujie Wang
    • 1
  1. 1.Department of Emergency SurgeryThe First Affiliated Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Clinical Medicine (5+3)Dalian Medical UniversityDalianChina

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