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Taurine 11 pp 705-715 | Cite as

Hot Water Extract of Loliolus beka Meat Attenuates H2O2-Induced Damage in Human Umbilical Vein Endothelial Cells

  • WonWoo Lee
  • Eui Jeong Han
  • Eun-Ji Shin
  • Hee-Jin Han
  • Ginnae AhnEmail author
  • Seon-Heui ChaEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Blood vessels become less flexible with senescence; arteries narrow and become less flexible, disturbing blood circulation in aging and other vascular diseases. Mechanistically, vascular senescence plays an important role in the pathogenesis of normal aging and age-related vascular diseases. Vascular senescence also causes vascular dysfunction, resulting in damage to the vessel wall. Vascular aging involves the senescence of endothelial cells. Hydrogen peroxide is widely used to achieve oxidative stress-induced premature senescence. Here, we investigated the protective effects of a hot water extract of Loliolus beka meat (LBM) against H2O2-exposed HUVECs, a human umbilical vein endothelial cells line. The hot water extract of LBM protected cells against H2O2-induced cytotoxicity while reducing the expression of senescence markers, including β-galactosidase, p53, and p21. In addition, the hot water extract of LBM protected against H2O2-induced DNA damage. These findings suggest that the hot water extract of LBM protects HUVECs from H2O2-induced senescence by preventing cellular damage. LBM serve as a supplement or natural food with benefits against vascular disease.

Keywords

Seaweed Loliolus beka meat Vasculadisease Endothelial Taurine Oxidative stress 

Notes

Acknowledgements

This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, & Future Planning (2017R1D1A1B03033794).

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Freshwater Biosources Utilization Bureau, Bioresources Industrialization Support DivisionNakdonggang National Institute of Biological Resources (NNIBR)SangjuRepublic of Korea
  2. 2.Department of Food Technology and NutritionChonnam National UniversityYeosuRepublic of Korea
  3. 3.Department of Marine Bio-Food SciencesChonnam National UniversityYeosuRepublic of Korea
  4. 4.Department of Marine BioindustryHanseo UniversitySeosanRepublic of Korea

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