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Taurine 11 pp 533-541 | Cite as

Anti-Cancer Mechanisms of Taurine in Human Nasopharyngeal Carcinoma Cells

  • Feng He
  • Ning Ma
  • Kaoru Midorikawa
  • Yusuke Hiraku
  • Shinji Oikawa
  • Yingxi Mo
  • Zhe Zhang
  • Kazuhiko Takeuchi
  • Mariko MurataEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Taurine displays anti-tumor activity in some kinds of human cancers. However, the underlying mechanisms are poorly understood. Epstein-Barr virus-related nasopharyngeal carcinoma (NPC) is a distinctive type of head and neck cancer in Southeast Asia with the highest incidence in South China. We examined an apoptosis-inducing effect of taurine against NPC cells (HK1 and HK1-EBV) to clarify the mechanisms of anti-tumor effects of taurine by immunocytochemical methods. We observed that taurine induced cleavage of caspase-9/3 in a concentration-dependent manner, suggesting the involvement of mitochondrial apoptotic signals. Both PTEN and p53 activation were detected in a dose-dependent manner after taurine treatment in NPC cells. In conclusion, taurine may play an anti-tumor role by activating tumor suppressor PTEN and p53.

Keywords

Taurine Nasopharyngeal carcinoma PTEN p53 

Notes

Acknowledgements

This work was supported in part by JSPS KAKENHI Grant Numbers JP16H05255 (MM).

References

  1. Chen H, Zhou L, Wu X, Li R, Wen J, Sha J, Wen X (2016) The PI3K/AKT pathway in the pathogenesis of prostate cancer. Front Biosci (Landmark Ed) 21:1084–1091CrossRefGoogle Scholar
  2. Cheng YL, Lee SC, Lin SZ, Chang WL, Chen YL, Tsai NM, Liu YC, Tzao C, Yu DS, Harn HJ (2005) Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo. Cancer Lett 222:183–193CrossRefGoogle Scholar
  3. Choi EJ, Tang Y, Lee CB, Cheong SH, Park PJ, Moon SH, Kim EK (2015) Investigation of antioxidant and anticancer potential of taurine by means of multiple chemical and biological assays. Adv Exp Med Biol 803:179–189CrossRefGoogle Scholar
  4. Cryns V, Yuan J (1998) Proteases to die for. Genes Dev 12:1551–1570CrossRefGoogle Scholar
  5. Dudgeon C, Kek C, Demidov ON, Saito S, Fernandes K, Diot A, Bourdon JC, Lane DP, Appella E, Fornace AJ Jr, Bulavin DV (2006) Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene. Cancer Res 66:2928–2936CrossRefGoogle Scholar
  6. Freeman JA, Espinosa JM (2013) The impact of post-transcriptional regulation in the p53 network. Brief Funct Genomics 12:46–57CrossRefGoogle Scholar
  7. Fulda S, Debatin KM (2006) Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25:4798–4811CrossRefGoogle Scholar
  8. He F, Ma N, Midorikawa K, Hiraku Y, Oikawa S, Zhang Z, Huang G, Takeuchi K, Murata M (2018) Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro. Amino Acids 50(12):1749–1758CrossRefGoogle Scholar
  9. Ibrahim HM, Abdel Ghaffar FR, El-Elaimy IA, Gouida MS, Abd El Latif HM (2018) Antitumor and immune-modulatory efficacy of dual-treatment based on levamisole and/or taurine in Ehrlich ascites carcinoma-bearing mice. Biomed Pharmacother 106:43–49CrossRefGoogle Scholar
  10. Jiang BH, Liu LZ (2009) PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res 102:19–65CrossRefGoogle Scholar
  11. Lee YR, Chen M, Pandolfi PP (2018) The functions and regulation of the PTEN tumour suppressor: new modes and prospects. Nat Rev Mol Cell Biol.  https://doi.org/10.1038/s41580-018-0024-zCrossRefGoogle Scholar
  12. Li HM, Man C, Jin Y, Deng W, Yip YL, Feng HC, Cheung YC, Lo KW, Meltzer PS, Wu ZG, Kwong YL, Yuen AP, Tsao SW (2006) Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase. Int J Cancer 119:1567–1576CrossRefGoogle Scholar
  13. Li P, Zhou L, Zhao T, Liu X, Zhang P, Liu Y, Zheng X, Li Q (2017) Caspase-9: structure, mechanisms and clinical application. Oncotarget 8:23996–24008PubMedPubMedCentralGoogle Scholar
  14. Lian W, Lian H, Li Q, An H, Liu S (2018) The venom of spider Haplopelma hainanum suppresses proliferation and induces apoptosis in hepatic cancer cells by caspase activation in vitro. J Ethnopharmacol.  https://doi.org/10.1016/j.jep.2018.06.022CrossRefGoogle Scholar
  15. Lo AK, Lo KW, Tsao SW, Wong HL, Hui JW, To KF, Hayward DS, Chui YL, Lau YL, Takada K, Huang DP (2006) Epstein-Barr virus infection alters cellular signal cascades in human nasopharyngeal epithelial cells. Neoplasia 8:173–180CrossRefGoogle Scholar
  16. Malkin D, Jolly KW, Barbier N, Look AT, Friend SH, Gebhardt MC, Andersen TI, Borresen AL, Li FP, Garber J et al (1992) Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. N Engl J Med 326:1309–1315CrossRefGoogle Scholar
  17. McDermott AL, Dutt SN, Watkinson JC (2001) The aetiology of nasopharyngeal carcinoma. Clin Otolaryngol Allied Sci 26:82–92CrossRefGoogle Scholar
  18. Poon RY (2014) DNA damage checkpoints in nasopharyngeal carcinoma. Oral Oncol 50:339–344CrossRefGoogle Scholar
  19. Que WC, Qiu HQ, Cheng Y, Liu MB, Wu CY (2018) PTEN in kidney cancer: a review and meta-analysis. Clin Chim Acta 480:92–98CrossRefGoogle Scholar
  20. Schaffer S, Kim HW (2018) Effects and mechanisms of taurine as a therapeutic agent. Biomol Ther (Seoul) 26:225–241CrossRefGoogle Scholar
  21. Tang Y, Choi EJ, Cheong SH, Hwang YJ, Arokiyaraj S, Park PJ, Moon SH, Kim EK (2015) Effect of taurine on prostate-specific antigen level and migration in human prostate cancer cells. Adv Exp Med Biol 803:203–214CrossRefGoogle Scholar
  22. Tsang CM, Zhang G, Seto E, Takada K, Deng W, Yip YL, Man C, Hau PM, Chen H, Cao Y, Lo KW, Middeldorp JM, Cheung AL, Tsao SW (2010) Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells: regulation of infection and phenotypic characterization. Int J Cancer 127:1570–1583CrossRefGoogle Scholar
  23. Tsao SW, Yip YL, Tsang CM, Pang PS, Lau VM, Zhang G, Lo KW (2014) Etiological factors of nasopharyngeal carcinoma. Oral Oncol 50:330–338CrossRefGoogle Scholar
  24. Tu S, Zhang XL, Wan HF, Xia YQ, Liu ZQ, Yang XH, Wan FS (2018) Effect of taurine on cell proliferation and apoptosis human lung cancer A549 cells. Oncol Lett 15:5473–5480PubMedPubMedCentralGoogle Scholar
  25. Wan J, Zhang J, Zhang J (2018) Expression of p53 and its mechanism in prostate cancer. Oncol Lett 16:378–382PubMedPubMedCentralGoogle Scholar
  26. Wang Z, Liao K, Zuo W, Liu X, Qiu Z, Gong Z, Liu C, Zeng Q, Qian Y, Jiang L, Bu Y, Hong S, Hu G (2017) Depletion of NFBD1/MDC1 induces apoptosis in nasopharyngeal carcinoma cells through the p53-ROS-mitochondrial pathway. Oncol Res 25:123–136CrossRefGoogle Scholar
  27. Yao JJ, Zhou GQ, Wang YQ, Wang SY, Zhang WJ, Jin YN, Zhang F, Li L, Liu LZ, Cheng ZB, Ma J, Qi ZY, Sun Y (2017) Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein-Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma. Chin J Cancer 36:98CrossRefGoogle Scholar
  28. Zhang X, Tu S, Wang Y, Xu B, Wan F (2014) Mechanism of taurine-induced apoptosis in human colon cancer cells. Acta Biochim Biophys Sin Shanghai 46:261–272CrossRefGoogle Scholar
  29. Zhang C, Jia X, Bao J, Chen S, Wang K, Zhang Y, Li P, Wan JB, Su H, Wang Y, Mei Z, He C (2016) Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways. BMC Complement Altern Med 16:58CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Feng He
    • 1
    • 2
    • 3
  • Ning Ma
    • 4
  • Kaoru Midorikawa
    • 1
  • Yusuke Hiraku
    • 1
  • Shinji Oikawa
    • 1
  • Yingxi Mo
    • 5
  • Zhe Zhang
    • 3
  • Kazuhiko Takeuchi
    • 2
  • Mariko Murata
    • 1
    Email author
  1. 1.Department of Environmental and Molecular MedicineMie University Graduate School of MedicineTsuJapan
  2. 2.Department of Otolaryngology Head and Neck SurgeryMie University Graduate School of MedicineTsuJapan
  3. 3.Department of Otolaryngology-Head and Neck SurgeryFirst Affiliated Hospital of Guangxi Medical UniversityNanningChina
  4. 4.Division of Health Science, Graduate School of Health ScienceSuzuka University of Medical ScienceSuzukaJapan
  5. 5.Department of ResearchAffiliated Tumor Hospital of Guangxi Medical UniversityNanningChina

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