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Taurine 11 pp 429-442 | Cite as

Pleiotropic Effects of Taurine on Nematode Model for Down Syndrome

  • Hyunsook Chang
  • Dong Hee LeeEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Taurine is traditionally used to treat Down Syndrome (DS); however, the actual foundation for this treatment is not well understood. DS patients suffer from disturbance of the proteostasis network (PN) due to aberrant calcium signaling, which eventually causes endoplasmic reticulum stress (ERS). Taurine has been suggested to play a role in modulating calcium homeostasis and ERS. This study examined whether taurine affects DS symptoms using C. elegans – a DS model in which calcineurins, Ca2+/calmodulin-dependent protein phosphatase is mutated to null. The DS nematode model has short body length, slow growth, fertility defects, serotonin-resistant egg-laying defects, and faulty thermal sensing. This study focused on whether taurine may ameliorate the severity of DS at the whole-body level, including reduction in ERS. When treated with taurine, DS nematodes appeared to have lower levels of ERS and phenotypes closer to the wild type. DS nematodes also showed improved egg laying efficiency and thermal sensing index comparable to the wild type. Our findings offer a new perspective on the effectiveness of taurine in treating DS and designing therapeutic strategies to lower ERS and restore disrupted PN.

Keywords

Calcineurin C. elegans Down syndrome DSCR-1 Taurine 

Abbreviation

DS

Down syndrome

DSCR-1

Down syndrome critical region 1

RCN

Regulator of calcineurin

Can a(b)

Calcineurin A(B)

NGM

Nematode growth medium

Notes

Acknowledgement

This research was supported by the Korea Nazarene University Reseach Grants 2019. 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Child StudiesKorea Nazarene UniversityChonan CitySouth Korea
  2. 2.Department of Life SciencesUniversity of SeoulSeoulSouth Korea

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