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Taurine 11 pp 35-44 | Cite as

Influences of Taurine Deficiency on Bile Acids of the Bile in the Cat Model

  • Teruo MiyazakiEmail author
  • Sei-ich Sasaki
  • Atsushi Toyoda
  • Mutsumi Shirai
  • Tadashi Ikegami
  • Yasushi Matsuzaki
  • Akira Honda
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Taurine content in the body is maintained by both biosynthesis from sulfur-contained amino acids in the liver and ingestion from usual foods, mainly seafoods and meat. Contrary to the rodents, the maintenance of taurine content in the body depends on the oral taurine ingestion in cats as well as humans because of the low ability of the biosynthesis. Therefore, insufficient of dietary taurine intake increases the risks of various diseases such as blind and expanded cardiomyopathy in the cats. One of the most established physiological roles of taurine is the conjugation with bile acid in the liver. In addition, taurine has effect to increase the expression and activity of bile acid synthesis rate-limiting enzyme CYP7A1. Present study purposed to evaluate the influence of taurine deficiency on bile acids in the cats fed taurine-lacking diet. Adult cats were fed the soybean protein-based diet with 0.15% taurine or without taurine for 30 weeks. Taurine concentration in serum and liver was undetectable, and bile acids in the bile were significantly decreased in the taurine-deficient cats. Taurine-conjugated bile acids in the bile were significantly decreased, and instead, unconjugated bile acids were significantly increased in the taurine-deficient cats. Present results suggested that the taurine may play an important role in the synthesis of bile acids in the liver.

Keywords

Bile acid Cats LC-MS/MS Liver Taurine deficiency 

Abbreviations

APDS

3-aminopyridyl-N-hydroxysuccinimidyl carbamate

BACS

ATP-dependent microsomal bile acid-CoA synthetase

BAT

bile acid-CoA:amino acid N-acetyltransferase

BW

body weight

CA

cholic acid

CDCA

chenodeoxycholic acid

CDO

cysteine dioxygenase

CSD

cysteine sulfinate decarboxylase

CYP7A1

cytochrome P450 7a1

DCA

deoxycholic acid

DIA

days in age

ESI

electrospray ionization

FXR

farnesoid X receptor

GCA

glycocholic acid

GCDCA

glycochenodeoxycholic acid

GDCA

glycodeoxycholic acid

GLCA

glycolithocholic acid

GUDCA

glycoursodeoxycholic acid

HDCA

hyodeoxycholic acid

LCA

lithocholic acid

MCA

muricholic acid

SRM

selected reaction monitoring

TCA

taurocholic acid

TCDCA

taurochenodeoxycholic acid

TDCA

taurodeoxycholic acid

TLCA

taurolithocholic acid

TUDCA

tauroursodeoxycholic acid

UDCA

ursodeoxycholic acid

UFLC

ultra-fast liquid chromatography

Notes

Acknowledgements

This research was supported in part by an Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM) (Ministry of Education, Culture, Sports, Science and Technology, Japan).

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Teruo Miyazaki
    • 1
    Email author
  • Sei-ich Sasaki
    • 2
    • 3
  • Atsushi Toyoda
    • 4
  • Mutsumi Shirai
    • 1
  • Tadashi Ikegami
    • 1
  • Yasushi Matsuzaki
    • 1
  • Akira Honda
    • 1
  1. 1.Tokyo Medical University Ibaraki Medical CenterIbarakiJapan
  2. 2.Ibaraki Prefectural University of Health SciencesIbarakiJapan
  3. 3.Toyo Public Health CollegeTokyoJapan
  4. 4.College of AgricultureIbaraki UniversityIbarakiJapan

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