Taurine 11 pp 25-34 | Cite as

Effects of Chronic Intake of a Low Concentration of Taurine on Physical Strength and Body Composition in Mice

  • Kyung Suk Cho
  • Manoj Kumar Neog
  • Joo Young Kim
  • Hyung-In Yang
  • Kyoung Soo KimEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)


Most studies of taurine on athletic performance have been conducted at acute and high doses in rodents. These doses and duration of administration are not reasonable for normal human life. Thus, it is not valid to extrapolate these animal results to people. Dose and duration that mimic human use of taurine in normal life can help to clarify the taurine effect in humans. This study investigated whether long-term, low-dose taurine (2% taurine drinking water for 25 weeks), similar to normal taurine intake in humans, can affect endurance exercise and body composition. Twenty ICR mice were divided into two groups. The control group received normal drinking water, and the taurine treated group received 2% taurine drinking water for 25 weeks. The mice were evaluated for body composition by mass and for physical strength by treadmill exhaustion and suspension tests. The supply of chronic 2% taurine drinking water has a slight effect on weight gain. In body composition analysis, a slight increase in body weight was due to an increase in muscle mass, not an increase in body fat. However, taurine ingestion did not increase endurance exercise. In conclusion, these results indirectly suggest that acute, high-dose taurine treatment is better than long-term, low-dose treatment to increase athletic performance.


Treadmill test Four-limb hanging test Athletic performance Body composition 



This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science, and Technology (Grant number 2017R1D1AB03031409 and 2018R1D1A1B07048706).


  1. Aruoma OI, Halliwell B, Hoey BM, Butler J (1988) The antioxidant action of taurine, hypotaurine and their metabolic precursors. Biochem J 256:251–255CrossRefGoogle Scholar
  2. Ballard SL, Wellborn-Kim JJ, Clauson KA (2010) Effects of commercial energy drink consumption on athletic performance and body composition. Phys Sportsmed 38:107–117CrossRefGoogle Scholar
  3. Chen G, Nan C, Tian J, Jean-Charles P, Li Y, Weissbach H, Huang XP (2012) Protective effects of taurine against oxidative stress in the heart of MsrA knockout mice. J Cell Biochem 113:3559–3566CrossRefGoogle Scholar
  4. Cuisinier C, Ward RJ, Francaux M, Sturbois X, de Witte P (2001) Changes in plasma and urinary taurine and amino acids in runners immediately and 24h after a marathon. Amino Acids 20:13–23CrossRefGoogle Scholar
  5. Fujita T, Ando K, Noda H, Ito Y, Sato Y (1987) Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 75:525–532CrossRefGoogle Scholar
  6. Geiss KR, Jester I, Falke W, Hamm M, Waag KL (1994) The effect of a taurine-containing drink on performance in 10 endurance-athletes. Amino Acids 7:45–56CrossRefGoogle Scholar
  7. Ito T, Yoshikawa N, Schaffer SW, Azuma J (2014) Tissue taurine depletion alters metabolic response to exercise and reduces running capacity in mice. J Amino Acids 2014:964680CrossRefGoogle Scholar
  8. Lombardini JB (1983) Effects of ATP and taurine on calcium uptake by membrane preparations of the rat retina. J Neurochem 40:402–406CrossRefGoogle Scholar
  9. Marcinkiewicz J, Kontny E (2014) Taurine and inflammatory diseases. Amino Acids 46:7–20CrossRefGoogle Scholar
  10. Matsuzaki Y, Miyazaki T, Miyakawa S, Bouscarel B, Ikegami T, Tanaka N (2002) Decreased taurine concentration in skeletal muscles after exercise for various durations. Med Sci Sports Exerc 34:793–797CrossRefGoogle Scholar
  11. Mizushima S, Nara Y, Sawamura M, Yamori Y (1996) Effects of oral taurine supplementation on lipids and sympathetic nerve tone. Adv Exp Med Biol 403:615–622CrossRefGoogle Scholar
  12. Mochizuki H, Oda H, Yokogoshi H (1998) Increasing effect of dietary taurine on the serum HDL-cholesterol concentration in rats. Biosci Biotechnol Biochem 62:578–579CrossRefGoogle Scholar
  13. Muller MJ, Geisler C, Pourhassan M, Gluer CC, Bosy-Westphal A (2014) Assessment and definition of lean body mass deficiency in the elderly. Eur J Clin Nutr 68:1220–1227CrossRefGoogle Scholar
  14. Murakami S, Kondo-Ohta Y, Tomisawa K (1999) Improvement in cholesterol metabolism in mice given chronic treatment of taurine and fed a high-fat diet. Life Sci 64:83–91CrossRefGoogle Scholar
  15. Pierno S, De Luca A, Camerino C, Huxtable RJ, Camerino DC (1998) Chronic administration of taurine to aged rats improves the electrical and contractile properties of skeletal muscle fibers. J Pharmacol Exp Ther 286:1183–1190PubMedGoogle Scholar
  16. van Putten M, Kumar D, Hulsker M, Hoogaars WM, Plomp JJ, van Opstal A, van Iterson M, Admiraal P, van Ommen GJ, t Hoen PA, Aartsma-Rus A (2012) Comparison of skeletal muscle pathology and motor function of dystrophin and utrophin deficient mouse strains. Neuromuscul Disord 22:406–417CrossRefGoogle Scholar
  17. Reymond I, Sergeant A, Tappaz M (1996) Molecular cloning and sequence analysis of the cDNA encoding rat liver cysteine sulfinate decarboxylase (CSD). Biochim Biophys Acta 1307:152–156CrossRefGoogle Scholar
  18. Ripps H, Shen W (2012) Review: taurine: a “very essential” amino acid. Mol Vis 18:2673–2686PubMedPubMedCentralGoogle Scholar
  19. Schaffer S, Kim HW (2018) Effects and mechanisms of taurine as a therapeutic agent. Biomol Ther (Seoul) 26:225–241CrossRefGoogle Scholar
  20. Shao A, Hathcock JN (2008) Risk assessment for the amino acids taurine, L-glutamine and L-arginine. Regul Toxicol Pharmacol 50:376–399CrossRefGoogle Scholar
  21. Waldron M, Patterson SD, Tallent J, Jeffries O (2018) The effects of an oral taurine dose and supplementation period on endurance exercise performance in humans: a meta-analysis. Sports Med 48:1247–1253CrossRefGoogle Scholar
  22. Yamori Y, Liu L, Mori M, Sagara M, Murakami S, Nara Y, Mizushima S (2009) Taurine as the nutritional factor for the longevity of the Japanese revealed by a world-wide epidemiological survey. Adv Exp Med Biol 643:13–25CrossRefGoogle Scholar
  23. Yatabe Y, Miyakawa S, Miyazaki T, Matsuzaki Y, Ochiai N (2003) Effects of taurine administration in rat skeletal muscles on exercise. J Orthop Sci 8:415–419CrossRefGoogle Scholar
  24. Yokogoshi H, Mochizuki H, Nanami K, Hida Y, Miyachi F, Oda H (1999) Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet. J Nutr 129:1705–1712CrossRefGoogle Scholar
  25. Zhang M, Izumi I, Kagamimori S, Sokejima S, Yamagami T, Liu Z, Qi B (2004) Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men. Amino Acids 26:203–207CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Kyung Suk Cho
    • 1
  • Manoj Kumar Neog
    • 2
  • Joo Young Kim
    • 1
  • Hyung-In Yang
    • 3
  • Kyoung Soo Kim
    • 1
    • 4
    Email author
  1. 1.Department of Clinical Pharmacology and Therapeutics, College of MedicineKyung Hee UniversitySeoulSouth Korea
  2. 2.School of Bio Sciences and TechnologyVIT UniversityVelloreIndia
  3. 3.Division of Rheumatology, Department of Internal MedicineKyung Hee University Hospital at GangdongGangdong-gu, SeoulSouth Korea
  4. 4.East-West Bone & Joint Disease Research InstituteKyung Hee University Hospital at GangdongGangdong-gu, SeoulSouth Korea

Personalised recommendations