Taurine 11 pp 13-24 | Cite as

Effect of Taurine on Intestinal Microbiota and Immune Cells in Peyer’s Patches of Immunosuppressive Mice

  • Hui Fang
  • Fanpeng Meng
  • Fengyuan Piao
  • Bo Jin
  • Ming Li
  • Wenzhe LiEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)


Taurine is a sulfur-containing amino acid which has strong activities in enhancing immunity. Gut microbiota is closely interrelated with intestinal mucosal immunity, but the effects and mechanisms of taurine on intestinal microbiota and mucosal immune cells under an immunosuppressive condition remain unclear. This study was conducted to investigate the effect of taurine on gut microbiota and immune cells in Peyer’s patches (PPs) of dexamethasone (Dex)-induced immunosuppressive mice. Mice (4-week-old, Male) were randomly divided into three groups: the Control group (n = 12), the Dex-induced immunosuppressive model group (n = 12) and the taurine intervention group (n = 12). The model was established by Dex injection for 7 days and the taurine intervention group was gavaged 100 mg/kg soluble taurine for 30 days. The changes of intestinal microbiota and immune cells in PPs were tested by denaturing gradient gel electrophoresis (DGGE) and flow cytometry, respectively. Results showed that the microbiota in immunosuppressive mice was obvious different compared with control group, in which, the Lachnospiraceae and Ruminococcaceae groups were significantly reduced, and their reduction were reversed after taurine intervention. Compared to the control group, the total cell number in PPs, as well as the subsets of CD3+ cells (T cells), CD19+ cells (B cells) in model groups were significantly lower, and they were dramatically improved after taurine treatment. Our results suggested that taurine has a positive effect on intestinal homeostasis of the immunosuppressive mice.


Taurine Microbiota Peyer’s patches Immune cells 



This work was supported by the National Nature Science Foundation of China (31570797, 81571498), the China Postdoctoral Science Foundation (2016M601317, 2018T110225), and the Research Foundation from the Department of Education, Liaoning Province, China (L2016003).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Hui Fang
    • 1
  • Fanpeng Meng
    • 2
  • Fengyuan Piao
    • 1
  • Bo Jin
    • 3
  • Ming Li
    • 1
  • Wenzhe Li
    • 1
    Email author
  1. 1.College of Basic Medical SciencesDalian Medical UniversityDalianChina
  2. 2.College of Life SciencesLiaoning Normal UniversityDalianChina
  3. 3.Fundamental and Applied Cryobiology Group, Reproductive and Genetic Medicine CenterDalian Municipal Women and Children’s Medical CenterDalianChina

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