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Taurine 11 pp 133-146 | Cite as

Taurine Improves Lipid Metabolism and Skeletal Muscle Sensitivity to Insulin in Rats Fed with High Sugar and High Fat Diet

  • Dongdong Zhao
  • Qiufeng Lv
  • Jiancheng Yang
  • Gaofeng Wu
  • Mei Liu
  • Qunhui Yang
  • Jie Han
  • Ying Feng
  • Shumei Lin
  • Jianmin Hu
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Metabolic syndrome is a lifestyle-related disease caused by high nutrient condition and lack of exercise. The insulin resistance due to obesity has attracted attention as an underlying mechanism of metabolic syndrome. Insulin resistance refers to reduced insulin sensitivity in insulin target tissues. In this case, in order to maintain normal blood glucose levels, a compensatory large amount of insulin is released, leading to the occurrence of hyperinsulinemia. Taurine is widely distributed in animal tissues. Although it is not involved in protein synthesis, taurine plays an important role in maintaining the body’s physiological function. In this experiment, insulin resistance model was induced by high fat and high sugar diet. Two percent taurine was added in drinking water to explore the mechanism of taurine in insulin resistance and to provide theoretical basis for using taurine to improve insulin resistance. The result showed that high-fat and high-sugar diet could decrease insulin sensitivity, and taurine could improve it by oral glucose tolerance test. Moreover, serum TG, TC were higher, while HDL-C in rats fed with high sugar and high fat diet was lower than normal rats, the changes of which can be significantly relieved by 2% taurine administration. mRNA and protein expressions of IRS1, and GLUT4 which were significantly changed by high sugar and high fat diet can also be regulated by 2% taurine. The results indicated that taurine can improve insulin sensitivity through remediating lipid metabolism disorder and regulating the expressions of IRS and GLUT4.

Keywords

Taurine Insulin resistance Lipid metabolism Rats 

Abbreviations

FBG

fasting glucose

FINS

fasting serum insulin levels

OGTT

oral glucose tolerance test

HOMA-IR

insulin resistance index

STZ

streptozotocin

IR

Insulin resistance

TC

total cholesterol

TG

triglyceride

HDL-C

high density lipoprotein cholesterol

IR

insulin receptor

IRS1

insulin receptor substrate 1

GLUT4

glucose transporter 4

Notes

Acknowledgements

This study was supported by grants from the Natural Sciences Funds, Republic of China (No. 31402160, 31872440, 31572481, 31872441).

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Dongdong Zhao
    • 1
  • Qiufeng Lv
    • 1
  • Jiancheng Yang
    • 1
  • Gaofeng Wu
    • 1
  • Mei Liu
    • 1
  • Qunhui Yang
    • 1
  • Jie Han
    • 1
  • Ying Feng
    • 1
  • Shumei Lin
    • 1
  • Jianmin Hu
    • 1
  1. 1.Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science & Veterinary MedicineShenyang Agricultural UniversityShenyangPeople’s Republic of China

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