Advertisement

Taurine 11 pp 119-131 | Cite as

Preventive or Curative Administration of Taurine Regulates Lipid Metabolism in the Liver of Rats with Alcoholic Liver Disease

  • Riyi Tang
  • Qunhui Yang
  • Shumei Lin
  • Ying Feng
  • Jiancheng Yang
  • Qiufeng Lv
  • Gaofeng Wu
  • Jianmin Hu
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Excessive consumption causes alcoholic liver disease (ALD), which injures hepatocytes and induces imbalance of lipid metabolism. Taurine is known to protect the liver from various liver injuries, and relieve lipid profile. Our previous studies also found that taurine can prevent or cure ALD, reduce fat deposition, but the mechanism remains unclear. In the present study, ALD rat model was established by administration of alcohol, pyrazole and high fat diet. Two percent taurine was administered at the same time or after ALD model establishment. Serum activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), serum and hepatic TC, TG, HDL-C and LDL-C were analyzed. Real-Time RT-PCR was conducted to detect the mRNA expressions of fatty acid synthetase (FAS), acetyl-CoA catboxylase (ACC), carnitine palmitoyl transferase 1 (CPT-1), 3-Hydroxy-3-methyl glutaric acid acyl Coenzyme A reductase (HMGCR), peroxisome proliferators activated receptor α (PPARα) and sterol regulatory element-binding protein 1c (SREBP-1c). The results showed that serum ALT, AST, serum and hepatic TC, TG and LDL-C were higher, while HDL-C in ALD model rats was lower than normal rats, the changes of which can be significantly relieved by taurine administration. mRNA expressions of ACC, FAS, CPT-1, HMGCR, PPARα and SREBP-1c which were significantly changed by ethanol can also be regulated by taurine. The results indicated that taurine can prevent and repair hepatic injury of ALD rats and balance lipid metabolism indexes in the liver, the mechanisms may involves in the regulation of related enzymes and transcriptional regulators participated in lipid metabolism.

Keywords

Taurine Alcoholic liver disease Lipid metabolism Rats 

Abbreviations

ALD

alcoholic liver disease

AFLD

alcoholic fatty liver disease

AH

alcoholic hepatitis

AF

alcoholic fibrosis

AC

alcoholic cirrhosis

ADH

acetaldehyde dehydrogenase

ALDH

aldehyde dehydrogenase

TG

triglyceride

TC

total cholesterol

LDL-C

low-density lipoprotein cholesterol

HDL-C

high-density lipoprotein cholesterol

ALT

alanine aminotransferase

AST

aspartate aminotransferase

ACC

acetyl-CoA catboxylase

FAS

fatty acid synthetase

CPT-1

carnitine palmitoyl transferase 1

HMGCR

3-Hydroxy-3-methyl glutaric acid acyl Coenzyme A reductase

PPARα

peroxisome proliferators activated receptor α

SREBP-1c

sterol regulatory element-binding protein 1c

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 31772694, 31872441 and 31302051).

References

  1. Abdel-Moneim AM, Al-Kahtani MA, El-Kersh MA, Al-Omair MA (2015) Free radical-scavenging, anti-inflammatory/anti-fibrotic and hepatoprotective actions of taurine and silymarin against CCl4 induced rat liver damage. PLoS One 10:e0144509.  https://doi.org/10.1371/journal.pone.0144509CrossRefPubMedPubMedCentralGoogle Scholar
  2. Bai T, Yang Y, Yao YL, Sun P, Lian LH, Wu YL, Nan JX (2016) Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway. Pharmacol Res 105:1–12CrossRefGoogle Scholar
  3. Balkan J, Kanbagli O, Aykac-Toker G, Uysal M (2002) Taurine treatment reduces hepatic lipids and oxidative stress in chronically ethanol-treated rats. Biol Pharm Bull 25:1231–1233CrossRefGoogle Scholar
  4. Bang CY, Byun JH, Choi HK, Choi JS, Choung SY (2016) Protective effects of ecklonia stolonifera extract on ethanol-induced fatty liver in rats. Biomol Ther 24:650–658CrossRefGoogle Scholar
  5. Bonfleur ML, Borck PC, Ribeiro RA, Caetano LC, Soares GM, Carneiro EM, Balbo SL (2015) Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine. Life Sci 135:15–21CrossRefGoogle Scholar
  6. Chang YY, Chou CH, Chiu CH, Yang KT, Lin YL, Weng WL, Chen YC (2011) Preventive effects of taurine on development of hepatic steatosis induced by a high-fat/cholesterol dietary habit. J Agric Food Chem 59:450–457CrossRefGoogle Scholar
  7. Chen Q et al (2017) Effects of natural products on fructose-induced nonalcoholic fatty liver disease (NAFLD). Nutrients 9:96.  https://doi.org/10.3390/nu9020096CrossRefPubMedCentralGoogle Scholar
  8. Cheong SH, Cho H, Chang KJ (2009) Effect of PTP1B inhibitors and taurine on blood lipid profiles in adolescent obesity. Adv Exp Med Biol 643:381–388CrossRefGoogle Scholar
  9. Chinetti G, Fruchart JC, Staels B (2001) Peroxisome proliferator-activated receptors (PPARs): nuclear receptors with functions in the vascular wall. Z Kardiol 90:125–132CrossRefGoogle Scholar
  10. Das J, Ghosh J, Manna P, Sil PC (2010) Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res 44:340–355CrossRefGoogle Scholar
  11. Dossi CG, Tapia GS, Espinosa A, Videla LA, D’Espessailles A (2014) Reversal of high-fat diet-induced hepatic steatosis by n-3 LCPUFA: role of PPAR-alpha and SREBP-1c. J Nutr Biochem 25:977CrossRefGoogle Scholar
  12. Edwards PA, Tabor D, Kast HR, Venkateswaran A (2000) Regulation of gene expression by SREBP and SCAP. Biochim Biophys Acta 1529:103CrossRefGoogle Scholar
  13. Engin A (2017) Non-alcoholic fatty liver disease. Adv Exp Med Biol 960:443–467CrossRefGoogle Scholar
  14. Gnoni A, Giudetti AM (2016) Dietary long-chain unsaturated fatty acids acutely and differently reduce the activities of lipogenic enzymes and of citrate carrier in rat liver. J Physiol Biochem 72:485–494CrossRefGoogle Scholar
  15. Hoang MH et al (2012) Taurine is a liver X receptor-alpha ligand and activates transcription of key genes in the reverse cholesterol transport without inducing hepatic lipogenesis. Mol Nutr Food Res 56:900–911CrossRefGoogle Scholar
  16. Hong J, Kim S, Kim HS (2016) Hepatoprotective effects of soybean embryo by enhancing adiponectin-mediated AMP-activated protein kinase alpha pathway in high-fat and high-cholesterol diet-induced nonalcoholic fatty liver disease. J Med Food 19:549–559CrossRefGoogle Scholar
  17. Ito T, Yoshikawa N, Schaffer SW, Azuma J (2014) Tissue taurine depletion alters metabolic response to exercise and reduces running capacity in mice. J Amino Acids 2014:964680CrossRefGoogle Scholar
  18. Jamshidzadeh A et al (2017) Taurine treatment preserves brain and liver mitochondrial function in a rat model of fulminant hepatic failure and hyperammonemia. Biomed Pharmacother 86:514–520CrossRefGoogle Scholar
  19. Jung JH, Kim HS (2013) The inhibitory effect of black soybean on hepatic cholesterol accumulation in high cholesterol and high fat diet-induced non-alcoholic fatty liver disease. Food Chem Toxicol 60:404–412CrossRefGoogle Scholar
  20. Kennelly PJ, Rodwell VW (1985) Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by reversible phosphorylation-dephosphorylation. J Lipid Res 26:903–914PubMedGoogle Scholar
  21. Kerai MDJ, Waterfield CJ, Kenyon SH, Asker DS, Timbrell JA (1998) Taurine: protective properties against ethanol-induced hepatic steatosis and lipid peroxidation during chronic ethanol consumption in rats. Amino Acids 15:53–76CrossRefGoogle Scholar
  22. Latchoumycandane C, Nagy LE, Mcintyre TM (2014) Chronic ethanol ingestion induces oxidative kidney injury through taurine-inhibitable inflammation. Free Radic Biol Med 69:403–416CrossRefGoogle Scholar
  23. Leggio L, Lee MR (2017) Treatment of alcohol use disorder in patients with alcoholic liver disease. Am J Med 130:124–134CrossRefGoogle Scholar
  24. Li HH et al (2014) Modulation of fatty acid and bile acid metabolism by peroxisome proliferator-activated receptor alpha protects against alcoholic liver disease. Alcohol Clin Exp Res 38:1520–1531CrossRefGoogle Scholar
  25. Lin S et al (2010) Preventive effect of taurine on experimental type II diabetic nephropathy. J Biomed Sci 17(Suppl 1):S46CrossRefGoogle Scholar
  26. Liu X, Zhang J, Ming Y, Chen X, Zeng M, Mao Y (2015) The aggravation of mitochondrial dysfunction in nonalcoholic fatty liver disease accompanied with type 2 diabetes mellitus. Scand J Gastroenterol 50:1152–1159CrossRefGoogle Scholar
  27. Liu Q et al (2017) Rutin exhibits hepatoprotective effects in a mouse model of non-alcoholic fatty liver disease by reducing hepatic lipid levels and mitigating lipid-induced oxidative injuries. Int Immunopharmacol 49:132–141CrossRefGoogle Scholar
  28. Livero FA et al (2016) Hydroethanolic extract of Baccharis trimera ameliorates alcoholic fatty liver disease in mice. Chem Biol Interact 260:22–32CrossRefGoogle Scholar
  29. Murakami S et al (2016) Taurine ameliorates cholesterol metabolism by stimulating bile acid production in high-cholesterol-fed rats. Clin Exp Pharmacol Physiol 43:372–378CrossRefGoogle Scholar
  30. Nammi S, Kim MS, Gavande NS, Li GQ, Roufogalis BD (2010) Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase expression by Zingiber officinale in the liver of high-fat diet-fed rats. Basic Clin Pharmacol Toxicol 106:389–395CrossRefGoogle Scholar
  31. Nan W, Sarna LK, Hwang SY, Zhu Q, Wang P, Siow YL, Karmin O (2013) Activation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase during high fat diet feeding. Biochim Biophys Acta (BBA) - Mol Basis Dis 1832:1560–1568CrossRefGoogle Scholar
  32. Orman ES, Odena G, Bataller R (2013) Alcoholic liver disease: pathogenesis, management, and novel targets for therapy. J Gastroenterol Hepatol 28(Suppl 1):77CrossRefGoogle Scholar
  33. Panyod S et al (2016) Diet supplementation with allicin protects against alcoholic fatty liver disease in mice by improving anti-inflammation and antioxidative functions. J Agric Food Chem 64:7104–7113CrossRefGoogle Scholar
  34. Rehm J, Shield KD (2013) Alcohol and mortality: global alcohol-attributable deaths from cancer, liver cirrhosis, and injury in 2010. Alcohol Res Curr Rev 35:174Google Scholar
  35. Schaffer SW, Azuma J, Mozaffari M (2009) Role of antioxidant activity of taurine in diabetes. Can J Physiol Pharmacol 87:91–99CrossRefGoogle Scholar
  36. Taranukhin AG, Saransaari P, Oja SS (2013) Lethality of taurine and alcohol coadministration in mice. Adv Exp Med Biol 776:29–38CrossRefGoogle Scholar
  37. Wang Z, Yao T, Song Z (2010) Chronic alcohol consumption disrupted cholesterol homeostasis in rats: down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver. Alcohol Clin Exp Res 34:471–478CrossRefGoogle Scholar
  38. Wu G, Yang J, Sun C, Luan X, Shi J, Hu J (2009) Effect of taurine on alcoholic liver disease in rats. Amino Acids 36:457–464CrossRefGoogle Scholar
  39. Wu G, Yang J, Lin S, Feng Y, Yang Q, Lv Q, Hu J (2013) Taurine and Chinese traditional medicine accelerate alcohol metabolism in mice. Adv Exp Med Biol 776:21–28CrossRefGoogle Scholar
  40. Wu G et al (2015) Taurine accelerates alcohol and fat metabolism of rats with alcoholic fatty liver disease. Adv Exp Med Biol 803:793–805CrossRefGoogle Scholar
  41. Yang W et al (2017) Betaine attenuates chronic alcohol-induced fatty liver by broadly regulating hepatic lipid metabolism. Mol Med Rep 16(4):5225–5234.  https://doi.org/10.3892/mmr.2017.7295CrossRefPubMedPubMedCentralGoogle Scholar
  42. Yao YL, Han X, Li ZM, Lian LH, Nan JX, Wu YL (2017) Acanthoic acid can partially prevent alcohol exposure-induced liver lipid deposition and inflammation. Front Pharmacol 8:134PubMedPubMedCentralGoogle Scholar
  43. Yildirim Z, Kilic N, Ozer C, Babul A, Take G, Erdogan D (2007) Effects of taurine in cellular responses to oxidative stress in young and middle-aged rat liver. Ann N Y Acad Sci 1100:553–561CrossRefGoogle Scholar
  44. Zammit VA (2008) Carnitine palmitoyltransferase 1: central to cell function. IUBMB Life 60:347CrossRefGoogle Scholar
  45. Zhang X, Wang H, Yin P, Fan H, Sun L, Liu Y (2017) Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice. Lipids Health Dis 16:44CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Riyi Tang
    • 1
  • Qunhui Yang
    • 1
  • Shumei Lin
    • 1
  • Ying Feng
    • 1
  • Jiancheng Yang
    • 1
  • Qiufeng Lv
    • 1
  • Gaofeng Wu
    • 1
  • Jianmin Hu
    • 1
  1. 1.Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science & Veterinary MedicineShenyang Agricultural UniversityShenyangPeople’s Republic of China

Personalised recommendations