Current Challenges with HDAC Inhibitor-Based Therapeutic Intervention Against Neurological Maladies

  • Shabir Ahmad Ganai


Histone deacetylase inhibitors (HDACi) have proved their mettle in treating hematological malignancies and are now emerging as propitious agents for tackling neurological complications. However, certain things limit their possible use as therapeutic agents for treating neuronal disorders. Thus this chapter details all the current therapeutic impediments in the pathway of HDACi. Among these roadblocks, lack of sufficient knowledge regarding the individual HDACs in neuronal diseases is one of the concerns, which is discussed. Further, this chapter sheds light on the lack of specificity of HDACi and high structural identity at the active sites of different HDACs. Importantly, the lack of blood-brain barrier permeability of HDACi restricting the use of these marvellous inhibitors against neurological disorders is detailed.


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Shabir Ahmad Ganai
    • 1
  1. 1.Division of Basic Sciences and Humanities, Faculty of AgricultureSKUAST-KashmirWadura SoporeIndia

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