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Synthesis of Thioamides

  • Toshiaki MuraiEmail author
Chapter

Abstract

Improved versions of traditionally employed synthetic reactions and newly developed synthetic reactions for thioamides and thiolactams reported within five years are introduced in this chapter. As starting materials, carbonyl compounds such as aldehydes, ketones, acids, amides, and esters are used in combination with elemental sulfur or other sulfur sources, and amines. Alkynes, benzylic halides, amines, and nitriles also provide the carbon atom of the C=S group. To achieve the direct replacement of the oxygen atom of ordinary amides with the sulfur atom, thionating reagents involving the P=S bonds are developed. Alternatively, reactive sulfur species are generated in situ.

Keywords

Willgerodt–Kindler reaction Thionation Isothiocyanates Thioacetic acids Thiocarbamoyl chlorides 

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Chemistry and Biomolecular Science, Faculty of EngineeringGifu UniversityGifuJapan

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