Update in the Investigation of von Willebrand Disease

  • Vishrut K. Srinivasan
  • Jasmina Ahluwalia


Von Willebrand disease (VWD) is the most common coagulation factor deficiency. The diagnosis of VWD is challenging because of the lack of a single diagnostic test that can be informative about the defects in different parts of the protein. The usual screening tests of coagulation may be normal. If the bleeding history is suggestive and family history for VWD is present, a panel of tests including antigen assay, ristocetin and collagen binding assays and at times multimer analysis may be required. Derived ratios of VWF antigen and activity assays are helpful to ascertain the phenotype of VWD. Most of these tests are available on automated coagulation analysers that have improved the lower limits of detection, precision and turnaround times. The ristocetin aggregation studies are useful in subtyping type 2B VWD. Genetic testing is required to confirm platelet type vs. type 2B VWD.


von Willebrand disease VWF antigen Ristocetin cofactor assay 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Vishrut K. Srinivasan
    • 1
  • Jasmina Ahluwalia
    • 1
  1. 1.Department of HematologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia

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