Flavones: Flavonoids Having Chemico-Biological Properties with a Preview into Anticancer Action Mechanism

  • Ajay Sharma
  • Hardeep Singh Tuli
  • Dharambir Kashyap
  • Anil K. Sharma


Flavones belong to the flavonoids class of plant polyphenols. Owing to their widespread distribution in plants, such as fruits, vegetables, herbs, spices, and beverages (tea, coffee, and wine), these compounds are consumed by human beings in large amounts through daily nutrition. This group of compounds occupies an inimitable position in the realm of natural, semisynthetic, and synthetic organic chemistry as well as biological sciences owing to their diversified valuable role in human health and their distinctive role in plants. Their structural features are responsible for the biochemical effects and therapeutic applications attributable to immune modulation and prevention of many diseases in humans. In this chapter, we address the requisite structural features of flavones for their biological and pharmacological significance in terms of structure activity relationship and chemical synthesis along with biosynthetic approaches and biological properties of some chemically modified derivatives. Also, the chapter highlights the mechanistic insight into the action of flavones mediating anticancer therapeutic effects.


Flavones Structure-function relationship Chemical synthesis Biological properties Anticancer effects Mechanism 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Ajay Sharma
    • 1
  • Hardeep Singh Tuli
    • 2
  • Dharambir Kashyap
    • 3
  • Anil K. Sharma
    • 2
  1. 1.Department of ChemistryCareer Point UniversityHamirpurIndia
  2. 2.Department of BiotechnologyMaharishi Markandeshwar (Deemed to be University) MullanaAmbalaIndia
  3. 3.Department of HistopathologyPostgraduate Institute of Medical Education and Research (PGIMER)ChandigarhIndia

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