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Mechanistic Insight into Cancer Aetiology and Therapeutic Management by Natural Metabolites

  • Vandana Singh
  • Deepak Kumar
  • Sheemona Chowdhary
  • Kunal Maniar
  • Meenu Narwal
  • Rajasri Bhattacharyya
  • Dibyajyoti Banerjee
Chapter

Abstract

The sudden and uncontrolled proliferation of cells is a common cause of mortality. Cancer is a multifactorial disorder which involves both exogenous and endogenous factors for initiation, promotion and progression. The interplay between genes and environment induces genetic and epigenetic alterations to cause chronic diseases including cancers. The management of cancer is far from addressing genetic and epigenetic alterations. The major limitation of current therapy is that it affects the non-targeted tissues also. In this respect, anticancer drugs which are derived from natural resources are considered as good leads for drug development. The natural products have shown anticancer activity in various types of cancer. Thus, the use of the natural product in cancer chemotherapy is gaining attention. In this chapter, the recent plant-derived secondary metabolites with potential for therapeutic management of cancer are discussed.

Keywords

Malignancy Cancer aetiology Cancer hallmarks Plant-derived natural products Cancer therapies Cancer chemoprevention 

Abbreviations

CDK1

Cyclin-dependent kinase 1

COX1

Cyclooxygenase 1

HBV

Hepatitis B virus

HIV

Human immunodeficiency virus

HPV

Human papilloma virus

IGF-1

Insulin growth factor-1

TME

Tumour microenvironment

VBL

Vinblastine

VCR

Vincristine

WA

Withaferin A

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Vandana Singh
    • 1
  • Deepak Kumar
    • 1
  • Sheemona Chowdhary
    • 1
  • Kunal Maniar
    • 2
  • Meenu Narwal
    • 3
  • Rajasri Bhattacharyya
    • 1
  • Dibyajyoti Banerjee
    • 1
  1. 1.Department of Experimental Medicine & BiotechnologyPostgraduate Institute of Medical Education & ResearchChandigarhIndia
  2. 2.Department of PharmacologyPostgraduate Institute of Medical Education & ResearchChandigarhIndia
  3. 3.Department of BiotechnologyMaharishi Markandeshwar (Deemed to be University)AmbalaIndia

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