Molecular Imaging and Targeted Therapy in Neurology
As the most common motor neurodegenerative disorder, Parkinson’s disease has been the second most common neurodegenerative disorder after Alzheimer’s disease (AD). The prevalence of Parkinson’s disease (PD) is around 1% at age 60 and 4–5% at 85. Bradykinesia is the most important symptoms in PD, and resting tremor, rigidity, and postural instability are the other three cardinal motor symptoms presented in the disease. Two main neuropathologies of PD are characterized by progressive cell loss of dopaminergic neurons predominately of the ventrolateral part of the pars compacta of the substantia nigra and the presence of Lewy pathology including Lewy bodies (LBs) and Lewy neurites (LNs).
- 17.Smailagic N, Vacante M, Hyde C et al (2015) 18F-FDG PET for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev (1):D10632Google Scholar
- 27.Damont A, Roeda D, Dollé F (2013) The potential of carbon-11 and fluorine-18 chemistry: illustration through the development of positron emission tomography radioligands targeting the translocator protein 18 kDa. J Labelled Comp Radiopharm 56(3–4):96–104. https://doi.org/10.1002/jlcr.2992CrossRefPubMedGoogle Scholar