Molecular Imaging and Targeted Therapy in Neurology
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As the most common motor neurodegenerative disorder, Parkinson’s disease has been the second most common neurodegenerative disorder after Alzheimer’s disease (AD). The prevalence of Parkinson’s disease (PD) is around 1% at age 60 and 4–5% at 85. Bradykinesia is the most important symptoms in PD, and resting tremor, rigidity, and postural instability are the other three cardinal motor symptoms presented in the disease. Two main neuropathologies of PD are characterized by progressive cell loss of dopaminergic neurons predominately of the ventrolateral part of the pars compacta of the substantia nigra and the presence of Lewy pathology including Lewy bodies (LBs) and Lewy neurites (LNs).
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