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ADF (Actin Depolymerizing Factor): The Breaker of the Polymer in Homeostasis

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Actin Polymerization in Apicomplexan

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Abstract

This chapter talks about the various isoforms of ADF that exist in different higher eukaryotes and its variation from apicomplexan ADF. We have discussed the structure, the function and the stability of the protein and the way it is regulated in different actin-mediated cellular processes to control the machinery of actin polymerization. ADF, an actin depolymerizing factor which exist in two isoforms in Plasmodium, has been well-studied in the current chapter. The structural difference of ADF from apicomplexan to its higher eukaryotic counterparts has been elucidated in this chapter. We have deduced a unique motif present in the apicomplexan ADF and have discussed about its plausible role in the regulation of actin depolymerization process. Finally, we also have briefed about the various regulators of ADF known in the literature.

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Authors and Affiliations

  1. School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences (CEBS), Mumbai, Maharashtra, India

    Samridhi Pathak, Ricka Gauba & Avinash Kale

  2. Department of Computer Science, Synthetic Biology Theme, Brunel University London, Uxbridge, UK

    Sarath Chandra Dantu

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  1. School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences (CEBS), Mumbai, Maharashtra, India

    Avinash Kale

5.1 Supplementary Electronic Material (S)

SF_ADF-1

The detailed alignment of all ADF1 and ADF2 from Plasmodium family with human cofilin (PDF 35 kb)

ST_ADF-1

Sequence comparison identity matrix for ADF proteins used in the current study (XLSX 63 kb)

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Pathak, S., Gauba, R., Dantu, S.C., Kale, A. (2019). ADF (Actin Depolymerizing Factor): The Breaker of the Polymer in Homeostasis. In: Kale, A. (eds) Actin Polymerization in Apicomplexan. Springer, Singapore. https://doi.org/10.1007/978-981-13-7450-0_5

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