The Preparation Technology of Pharmaceutical Preparations of Lactic Acid Bacteria

  • Wei ChenEmail author
  • Linlin Wang


The application of lactic acid bacteria in medicine mainly originates from the efficacy of food. In 1906 Metchnikoff suggested that bacteria in yogurt are good for human health. Later, according to the phenomenon that yogurt can inhibit the growth of acid-tolerant bacteria, he assumed that similar phenomena will appear in the human intestine. The bacteria in the yogurt protect human health from spoilage bacteria by making some spoilage bacteria fail to proliferate and cannot produce toxic substances. This argument became a popular medical topic in Western Europe at the time. Following the first successful use of bacteria to treat diseases, Daviel Newman applied lactic acid bacteria to treat bladder infections and pointed out that the reason for the cure is that the lactic acid produced by the metabolism of lactic acid bacteria has anti-infective properties. However, because of the exhaustive information provided, the simple sample, and the lacking basic characteristics of the strain, the mechanism cannot be clarified. However, this finding laid the foundation for the clinical application of lactic acid bacteria. Subsequently, Rettger et al. made a lot of research on the role and application of Lactobacillus acidophilus in 1935, which made people to have a strong interest in yogurt once again. They agreed that yogurt has a mitigating effect on constipation, inflammatory bowel disease (IBD), bacterial dysentery, obesity, and other diseases. So far, yogurt has prevailed in Europe and other places.


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© Springer Nature Singapore Pte Ltd. and Science Press 2019

Authors and Affiliations

  1. 1.Jiangnan UniversityWuxiChina

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