Advertisement

The Preparation Technology of Pharmaceutical Preparations of Lactic Acid Bacteria

  • Wei ChenEmail author
  • Linlin Wang
Chapter

Abstract

The application of lactic acid bacteria in medicine mainly originates from the efficacy of food. In 1906 Metchnikoff suggested that bacteria in yogurt are good for human health. Later, according to the phenomenon that yogurt can inhibit the growth of acid-tolerant bacteria, he assumed that similar phenomena will appear in the human intestine. The bacteria in the yogurt protect human health from spoilage bacteria by making some spoilage bacteria fail to proliferate and cannot produce toxic substances. This argument became a popular medical topic in Western Europe at the time. Following the first successful use of bacteria to treat diseases, Daviel Newman applied lactic acid bacteria to treat bladder infections and pointed out that the reason for the cure is that the lactic acid produced by the metabolism of lactic acid bacteria has anti-infective properties. However, because of the exhaustive information provided, the simple sample, and the lacking basic characteristics of the strain, the mechanism cannot be clarified. However, this finding laid the foundation for the clinical application of lactic acid bacteria. Subsequently, Rettger et al. made a lot of research on the role and application of Lactobacillus acidophilus in 1935, which made people to have a strong interest in yogurt once again. They agreed that yogurt has a mitigating effect on constipation, inflammatory bowel disease (IBD), bacterial dysentery, obesity, and other diseases. So far, yogurt has prevailed in Europe and other places.

References

  1. Bao X-h, Shen w-m, Shen y-f (1998) Experimental analysis and application of micro-ecological health products. Bull Sci Technol 27(2):61–64Google Scholar
  2. Bleau C, Monges A, Rashidan K et al (2010) Intermediate chains of exopolysaccharides from Lactobacillus rhamnosus RW-9595M increase IL-10 production by macrophages. J Appl Microbiol 108(2):666–675CrossRefGoogle Scholar
  3. Chen Q (2007) Bifidobacterium and Clostridium butyricum combined treatment of infants with lactose intolerance in 72 cases. Tianjin Med J 35(3):237Google Scholar
  4. Chen J-k, Weng W (2005) A technique of double layer embedment Lactobacillus and biological activity of embedded bacterium. Acta Agric Boreali-Occidentalis Sin 14(6):191–194Google Scholar
  5. Chytilová M, Nemcová R, Gancarčíková S et al (2014) Flax-seed oil and Lactobacillus plantarum supplementation modulate TLR and NF-κB gene expression in enterotoxigenic Escherichia coli challenged gnotobiotic pigs. Acta Vet Hung 64(4):463–472CrossRefGoogle Scholar
  6. Dong H, Rowland I, Yaqoob P (2012) Comparative effects of six probiotic strains on immune function in vitro. Br J Nutr 108(3):459–470CrossRefGoogle Scholar
  7. Elmadfa I, Klein P, Meyer AL (2010) Immune-stimulating effects of lactic acid bacteria in vivo and in vitro. Proc Nutr Soc 69(3):416–420CrossRefGoogle Scholar
  8. Gu Y-h, Zhang J-s, An H-r et al (2012) HAO Yan-ling screening of β-galactosidase highly producing Lactobacillus plantarum and its enzymatic properties. Zhonggue Rupin Gongye 40(9):8–10Google Scholar
  9. Hiramatsu Y, Hosono A, Konno T et al (2011) Orally administered Bifidobacterium triggers immune responses following capture by CD11c (+) cells in Peyer’s patches and cecal patches. Cytotechnology 63(3):307–317CrossRefGoogle Scholar
  10. Huang Y (2000) Lizhuchangle treatment of 29 cases of chronic diarrhea in children. Chin J Microecol 12(6):321–321Google Scholar
  11. Huang L, Li f-x (1999) Clinical observation of bifidobacteria live preparation for treating diarrhea. Chin J Microecol 11(2):96Google Scholar
  12. Kolars JC, Levitt MD, Aouji M et al (1984) Yogurt—an autodigesting source of lactose. N Engl J Med 310(1):1–3CrossRefGoogle Scholar
  13. Lee JW, Lee JH, Sung SH et al (2013) Preventive effects of lactobacillus mixture on experimental E. coli urinary tract infection in infant rats. Yonsei Med J 54(2):489–493CrossRefGoogle Scholar
  14. Li Q-H, Tang G-H, Zhong M-M et al (1998) The short-term effect of oral Bifidobacterium Lizhuchang on chronic diarrhea. Chin J Micro-Ecol 10(1):45Google Scholar
  15. Li Y-h, Ma L, Gu L-m et al (1999) Clinical observation of double fork milk for liver disease and intestinal endotoxemia. Chin J Micro-Ecol 11(3):153Google Scholar
  16. Li J, Zhang W, Wang C et al (2012) Lactococcus lactis expressing food-grade beta-galactosidase alleviates lactose intolerance symptoms in post-weaning Balb/c mice. Appl Microbiol Biotechnol 96(6):1499–1506CrossRefGoogle Scholar
  17. Liu Y-h, Zhao J-b, Lv X-f (2004) Application of microencapsulation technology in probiotic products. Food Mach 20(2):58–60Google Scholar
  18. Lomer MC, Parkes GC, Sanderson JD (2008) Review article: lactose intolerance in clinical practice – myths and realities. Aliment Pharmacol Ther 27(2):93–103CrossRefGoogle Scholar
  19. Luo J-x, Lin M-x, Xie J-P et al (1999) Clinical observation of Huichunsheng in treating pediatric diarrhea. Chin J Micro-Ecol 11(1):41Google Scholar
  20. Ma M-r, Zhu G-j (1999) Research progress on microbial-derived cholesterol-lowering drugs. Chin J New Drug 8(9):603–605Google Scholar
  21. Macfarlane GT, Cummings JH (1999) Probiotics and prebiotics: can regulating the activities of intestinal bacterial benefit health. Br Med J 318:999–1003CrossRefGoogle Scholar
  22. Mackie RI, Sghir A, Gaskins HR (1999) Developmental microbial ecology of the neonatal gastrointestinal tract. Am J Clin Nutr 69(suppl):1035S–1045SCrossRefGoogle Scholar
  23. Pochart P, Dewit O, Desjeux JF et al (1989) Viable starter culture, beta-galactosidase activity, and lactose in duodenum after yogurt ingestion in lactase-deficient humans. Am J Clin Nutr 49(5):828–831CrossRefGoogle Scholar
  24. Rabot S, Rafter JG (2010) Guidance for substantiating the evidence for beneficial effects of probiotics: impact of probiotics on digestive system metabolism. J Nutr 140(3):677S–689SCrossRefGoogle Scholar
  25. Reid G, Cook RL, Bruce AW (1987) Examination of strains of lactobacilli for properties that may influence bacterial interference in the urinary tract. J Urol 138(2):330–335CrossRefGoogle Scholar
  26. Reid G, Bruce AW, Mcgroarty JA et al (1990) Is there a role for lactobacilli in prevention of urogenital and intestinal infections. Clin Microbiol Rev 3(4):335CrossRefGoogle Scholar
  27. Savaiano DA (2014) Lactose digestion from yogurt: mechanism and relevance. Am J Clin Nutr 99(5 Suppl):1251S–1255SCrossRefGoogle Scholar
  28. Shao J-j, Zhu R-l (2003) The role of micro-ecological preparations and the problems that should be paid attention to in application. Sichuan Anim Vet Sci 30(9):45–46Google Scholar
  29. Skarin A, Sylwan J (1986) Vaginal lactobacilli inhibiting growth of Gardnerella vaginalis, Mobiluncus and other bacterial species cultured from vaginal content of women with bacterial vaginosis. Acta Pathol Microbiol Immunol Scand B 94B(1–6):399–403Google Scholar
  30. Soltan Dallal MM, Yazdi MH, Holakuyee M et al (2012) Lactobacillus casei ssp. casei induced Th1 cytokine profile and natural killer cells activity in invasive ductal carcinoma bearing mice. Iran J Allergy Asthma Immunol 11(2):183–189PubMedGoogle Scholar
  31. Song Y-l, Li H-y, Liu C-j (2010) Research progress in the treatment of lactose intolerance by lactic acid bacteria. Chin J Micro-Ecol 22(8):751–753Google Scholar
  32. Vincent V, Aghajari N, Pollet N et al (2012) The acid tolerant and cold-active β-galactosidase from Lactococcus lactis strain is an attractive biocatalyst for lactose hydrolysis. Antonie Van Leeuwenhoek 103(4):701–712CrossRefGoogle Scholar
  33. Wang Y, Cai F, Song G (1995) Therapeutic effect of lactic acid bacteria tablets in the treatment of 44 cases of diarrhea. Changzhi Med J (4):308Google Scholar
  34. Wang J, Wang C, Li X-h (2000) Clinical observation of Golden bifidus in the treatment of acute and chronic diarrhea. Chin J Micro-Ecol 12(1):32Google Scholar
  35. Xu J, Zou J, Yuan J (2011) Study on the effect of lactic acid bacteria on cholesterol lowering in high fat mice. Chin J Micro-Ecol 1:5–7Google Scholar
  36. Xue Y, Yang Y (2008) New progress in lactic acid bacteria genomics and genetic engineering. Mod Food Sci Technol 24(6):617–620Google Scholar
  37. Yan J, Li M, Zhong J et al (1987) Survey of lactose absorption and intolerance in milk and yogurt in normal adults. J Nutr 36(2):154–157Google Scholar
  38. Yang Y, Li Y, Shi T (1999) Clinical observation of Huichunsheng in the treatment of neonatal diarrhea. Chin J Micro-Ecol 11(5):290Google Scholar
  39. Yi X, Yang Y, Chen J et al (2006) Clinical observation of lactic acid bacteria vaginal capsule combined with metronidazole in the treatment of bacterial vaginosis. Cap Med 6(12):43Google Scholar
  40. Yu M, Huo J, Yang J (1998) The role and development trend of micro-ecological regulators. Chin J Micro-Ecol 2:117–119Google Scholar
  41. Zhang R (2007) Scientific use of microbial feed additives. Feed Livest 6:5–8Google Scholar
  42. Zou J, Yang J (2007) Application and prospect of probiotic lactic acid bacteria in the field of medicine. Heilongjiang Med 20(1):28–30Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and Science Press 2019

Authors and Affiliations

  1. 1.Jiangnan UniversityWuxiChina

Personalised recommendations