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Cataract with Infective Etiology

  • Chirakshi Dhull
  • Sudarshan Kumar Khokhar
Chapter

Abstract

Infectious etiology may play a role in cataract formation during embryogenesis [1, 2]. Toxoplasma, Rubella, Cytomegalovirus (CMV), Herpes Simplex virus (HSV), and others including syphilis commonly referred to as TORCH infections have been associated with congenital cataract formation especially in developing countries [3–5]. In addition to childhood cataract, ocular manifestations of TORCH infections include chorioretinitis, microphthalmos, keratitis, iridocyclitis, iris atrophy, glaucoma, optic neuritis, and retinitis [6].

References

  1. 1.
    Matoba A. Ocular viral infections. Pediatr Infect Dis. 1984;3:358–68.CrossRefGoogle Scholar
  2. 2.
    Cotlier E. Congenital varicella cataract. Am J Ophthalmol. 1978;86:627–9.CrossRefGoogle Scholar
  3. 3.
    Mahalakshmi B, Therese KL, Devipriya U, Pushpalatha V, Margarita S, Madhavan HN. Infectious aetiology of congenital cataract based on TORCHES screening in a tertiary eye hospital in Chennai, Tamil Nadu, India. Indian J Med Res. 2010;131:559–64.PubMedGoogle Scholar
  4. 4.
    Raghu H, Subhan S, Jose RJ, Gangopadhyay N, Bhende J, Sharma S. Herpes simplex virus-1-associated congenital cataract. Am J Ophthalmol. 2004;138:313–4.CrossRefGoogle Scholar
  5. 5.
    Madhavan HN. Laboratory investigations on viral and chlamydia trachomatis infections of the eye: Sankara Nethralaya experiences. Indian J Ophthalmol. 1999;47:241–6.PubMedGoogle Scholar
  6. 6.
    Mets MB. Eye manifestations of intrauterine infections. Ophthalmol Clin N Am. 2001;14:521–31.CrossRefGoogle Scholar
  7. 7.
    Mahalakshmi B, Therese KL, Shyamala G, Devipriya U, Madhavan HN. Toxoplasma gondii detection by nested polymerase chain reaction in lens aspirate and peripheral blood leukocyte in congenital cataract patients - the first report from a tertiary eye hospital in India. Curr Rye Res. 2007;32:653–7.Google Scholar
  8. 8.
    Shyamala G, Sowmya P, Madhavan HN, Malathi J. Relative efficiency of polymerase chain reaction and enzyme-linked immunosorbant assay in determination of viral etiology in congenital cataract in infants. J Postgrad Med. 2008;54:17–20.CrossRefGoogle Scholar
  9. 9.
    Lu B, Yang Y. Detection of TORCH pathogens in children with congenital cataracts. Exp Ther Med. 2016;12(2):1159–64.CrossRefGoogle Scholar
  10. 10.
    Vutova K, Peicheva Z, Popova A, Markova V, Mincheva N, Todorov T. Congenital toxoplasmosis: eye manifestations in infants and children. Ann Trop Paediatr. 2002;22:213–8.CrossRefGoogle Scholar
  11. 11.
    Datta S, Banerjee DP. Chorioretinitis in congenital toxoplasmosis. Indian Pediatr. 2003;40:790–1.PubMedGoogle Scholar
  12. 12.
    Mittal V, Bhatia R, Singh VK, Sengal S. Low incidence of congenital toxoplasmosis in Indian children. J Trop Pediatr. 1995;41:62–3.CrossRefGoogle Scholar
  13. 13.
    O’Neill JF. The ocular manifestations of congenital infection: a study of the early effect and long-term outcome of maternally transmitted rubella and toxoplasmosis. Trans Am Ophthalmol Soc. 1998;96:813–79.PubMedPubMedCentralGoogle Scholar
  14. 14.
    Boniuk I. The cytomegalovirus and the eye. Int Ophthalmol Clin. 1972;12:169–90.PubMedGoogle Scholar
  15. 15.
    Tarkkanen A, Merenmies L, Holmstrom T. Ocular involvement in congenital cytomegalic inclusion disease. J Pediatr Ophthalmol. 1972;9:82–6.Google Scholar
  16. 16.
    Hittner HM, Desmond MM, Montgomery JR. Optic nerve manifestations of human congenital cytomegalovirus infection. Am J Ophthalmol. 1976;81:661–5.CrossRefGoogle Scholar
  17. 17.
    Gregg NM. Congenital cataract following German measles in the mother. Trans Ophthalmol Soc Aust. 1941;3:35–46.Google Scholar
  18. 18.
    Papania MJ, Wallace GS, Rota PA, Icenogle JP, Fiebelkorn AP, Armstrong GL, Reef SE, Redd SB, Abernathy ES, Barskey AE, Hao L, McLean HQ, Rota JS, Bellini WJ, Seward JF. Elimination of endemic measles, rubella, and congenital rubella syndrome from the Western hemisphere; the US experience. JAMA Pediatr. 2014;168:148–55.CrossRefGoogle Scholar
  19. 19.
    Sheridan E, Aitken C, Jeffries D, Hird M, Thayalasekaran P. Congenital rubella syndrome: a risk in immigrant populations. Lancet. 2002;359:674–5.CrossRefGoogle Scholar
  20. 20.
    World Health Organization. Surveillance guidelines for measles, rubella and congenital rubella syndrome in the WHO European Region. http://www.euro.who.int/__data/assets/pdf_file/0018/79020/e93035-2013.pdf?ua=1.
  21. 21.
    Cooper LZ, Ziring PR, Ockerse AB, Fedun BA, Kiely B, Krugman S. Rubella clinical manifestations and management. Am J Dis Child. 1969;118:18–9.CrossRefGoogle Scholar
  22. 22.
    Vijayalakshmi P, Kakkar G, Samprathi A, et al. Ocular manifestations of congenital rubella syndrome in a developing country. Indian J Ophthalmol. 2002;50:307–11.PubMedGoogle Scholar
  23. 23.
    Vijayalakshmi P, Rajasundari TA, Prasad NM, et al. Prevalence of eye signs in congenital rubella syndrome in South India: a role for population screening. Br J Ophthalmol. 2007;91:1467–70.CrossRefGoogle Scholar
  24. 24.
    Boger WP III, Petersen RA, Robb RM. Spontaneous absorption of the lens in the congenital rubella syndrome. Arch Ophthalmol. 1981;99:433–4.CrossRefGoogle Scholar
  25. 25.
    Williams LL, Lew HM, Davidorf FH, et al. Altered membrane fatty acids of cultured human retinal pigment epithelium persistently infected with rubella virus may affect secondary cellular function. Arch Virol. 1994;134:379–92.CrossRefGoogle Scholar
  26. 26.
    Vijayalakshmi P, Srivastava KK, Poornima B, et al. Visual outcome of cataract surgery in children with congenital rubella syndrome. J AAPOS. 2003;7:91–5.CrossRefGoogle Scholar
  27. 27.
    Shah SK, Praveen MR, Vasavada AR, Vasavada VA, Carelli R, Trivedi RH, Rasoebala V. Long-term longitudinal assessment of postoperative outcomes after congenital cataract surgery in children with congenital rubella syndrome. J Cataract Refract Surg. 2014;40:2091–8.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Chirakshi Dhull
    • 1
  • Sudarshan Kumar Khokhar
    • 1
  1. 1.Dr Rajendra Prasad Centre for Ophthalmic SciencesAll India Institute of Medical SciencesNew DelhiIndia

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