In-silico Targets in Immune Response
Robust and non-specific innate immune system and much specific adaptive immune system protect higher animals from harmful particles and antigens. Immunological research in last few decades has successfully illustrated the functional components and structural units of immune system. Biology of major immune responses against foreign or self-antigens are well classified and have been used extensively in biomedical sciences. Differential expressivity, multiple epitopes, array of newer/unknown antigens and heterogeneous host and pathogen genetic background has emerged as a major challenge. Technological advancements, high-throughput data generation and analysis have facilitated in studying biological systems more rapidly and efficiently. Such systems biology approach has been applied recently to decipher complex immune systems. In silico studies of conceptualization, stratification and several model based prediction of immune responses are known as immunoinformatics, which are being used extensively. In this chapter we have discussed several available in silico tools to study immune responses.
KeywordImmunoinformatics Natural products Immune response
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