Metastatic tumors are the most common type of malignancy in the liver, far exceeding primary tumors of the liver. The distinction between a primary tumor and a metastatic tumor in the liver has both therapeutic and prognostic significance. Knowledge of the primary tumor site and its morphology, if available, is important in evaluating and comparing it to its metastasis. Among tumor types, adenocarcinoma, neuroendocrine tumor, and lymphoma are the most common. Common primary sites include the colon (adenocarcinoma), pancreas (adenocarcinoma and pancreatic neuroendocrine tumor), stomach and small intestine (adenocarcinoma, neuroendocrine and gastrointestinal stromal tumor), lung (adenocarcinoma, small-cell and large-cell neuroendocrine carcinoma, and squamous cell carcinoma), breast, skin (melanoma), and kidney (renal cell carcinoma).
KeywordsMetastasis Liver Tumor Metastatic tumor
Prof. Alex Y. Chang was a coauthor of the first edition of this chapter.