Liver Disorders in Systemic Diseases

  • Masaki Iwai
  • Kenichi Miyoshi
  • Masahiko Koda
  • Wilson M. S. TsuiEmail author


Liver disease may occur in association with various systemic diseases. These primary diseases are predominantly extrahepatic, but associated hepatic dysfunction may develop and often is of clinical significance and diagnostic importance. In some cases, liver disease simply represents a manifestation of the systemic disease process involving the liver, as in disseminated malignancy, systemic infection, and some metabolic diseases. Rarely, it may constitute a relatively unique manifestation of a systemic disease, as in primary sclerosing cholangitis associated with ulcerative colitis.



Acquired immunodeficiency syndrome


Absolute neutrophil count


Combination chemotherapy-Mustargen, oncovin, procarbazine, prednisone-Adriamycin, bleomycin, vinblastine, dacarbazine


Calcinosis cutis, Raynaud’s phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia


Disseminated intravascular coagulopathy


Extramedullary hemopoiesis


Hemolysis, elevated liver tests, and low platelets


Inflammatory bowel disease


Mucosa-associated lymphoid tissue


Multidrug resistance protein 3


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Masaki Iwai
    • 1
  • Kenichi Miyoshi
    • 2
  • Masahiko Koda
    • 2
  • Wilson M. S. Tsui
    • 3
    Email author
  1. 1.KyotoJapan
  2. 2.TottoriJapan
  3. 3.Hong KongChina

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