Granulomatous Liver Diseases

  • Masako Mishima
  • Masahiko Koda
  • Wilson M. S. Tsui


Hepatic granulomas develop through the interactions of T lymphocytes and macrophages. Granulomas are relatively common in liver samples, identified in 2–10% of cases. Granuloma formation is mainly due to infections, sarcoidosis, drug reactions, and primary biliary cholangitis. This article concisely reviews the classification, etiology, pathophysiology, clinical presentation, diagnosis, and treatment options of granulomatous liver diseases.


Granuloma Kupffer cell Lipogranuloma An epithelioid granuloma An inflammatory granuloma Sarcoidosis Primary biliary cholangitis Hepatic tuberculosis Bacillus Calmette-Guerin Syphilis Schistosomiasis Drug Lymphoma 



Bacillus Calmette-Guerin


Human immunodeficiency virus


Primary biliary cholangitis


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Masako Mishima
    • 1
  • Masahiko Koda
    • 2
  • Wilson M. S. Tsui
    • 3
  1. 1.KyotoJapan
  2. 2.TottoriJapan
  3. 3.Hong KongChina

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