Advertisement

Genotoxicity and Toxicological Studies

  • Jayanta Kumar Patra
  • Swagat Kumar Das
  • Gitishree Das
  • Hrudayanath Thatoi
Chapter
Part of the Learning Materials in Biosciences book series (LMB)

Abstract

Genotoxicity can be defined as the toxic changes on the genetic material (DNA, RNA) of the cell leading to destruction of nucleotide strand breakage. Genotoxins are the mutagens and cause genotoxicity by damaging chromosomal material causing mutation. Genotoxins includes both chemical substance and radiation. Genetic material damage in somatic cells may lead to malignancy whereas damage in germ cells may lead to heritable mutations causing various birth defects. Therefore, assessment of genotoxicity is important for evaluation of safety aspects of substances for protection of health and the environment. The results of the genotoxicity tests form the scientific basis for risk assessment and are used for classification and labelling of chemical substances.

References

  1. Badyal D (2008) Practical manual of pharmacology. Jaypee Brothers Medical Publishers, New DelhiCrossRefGoogle Scholar
  2. BM Swamy V, Jayaveera KN, Reddy V (2014) Experimental pharmacology and toxicology. S. Chand & Company, New DelhiGoogle Scholar
  3. Corvi R, Madia F (2017) In vitro genotoxicity testing – can the performance be enhanced? Food Chem Toxicol 106:600–608CrossRefGoogle Scholar
  4. Goyal RK (2017) Practical in pharmacology. B. S. Shah Prakashan, AhmedabadGoogle Scholar
  5. Kale SR, Kale RR (2017) Practical pharmacology and toxicology. Nirali Prakashan, MumbaiGoogle Scholar
  6. Katzung BG, Masters SB, Trevor AJ (2012) Basic & clinical pharmacology. McGraw-Hill, New YorkGoogle Scholar
  7. Medhi B (2017) Practical manual of experimental and clinical pharmacology. Jaypee Brothers Medical Publishers, New DelhiGoogle Scholar
  8. Ostling O, Johanson KJ (1984) Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem Biophys Res Commun 123:291–298Google Scholar
  9. Ritter JM, Lewis LD, Mant TGK, Ferro A (2008) A text book of clinical pharmacology and therapeutics. Hodder Arnold, LondonCrossRefGoogle Scholar
  10. Salmon DM (2014) Practical pharmacology for the pharmaceutical sciences. Wiley, ChichesterGoogle Scholar
  11. Sierra LM, Gaivao I (eds) (2014) Genotoxicity and DNA repair: a practical approach. Springer protocols. Humana Press, LondonGoogle Scholar
  12. Singhal KC (1997) Pharmacology laboratory manual. CBS Publishers & Distributor, New DelhiGoogle Scholar
  13. Thatoi HN, Dash S, Das SK (2017) Practical biotechnology, principle and protocols. I.K. International, New DelhiGoogle Scholar
  14. Tripathi KD (2013) Essentials of medical pharmacology. Jaypee Brothers Medical Publishers, New DelhiGoogle Scholar
  15. Turner RA, Hebborn P (eds) (1971) Screening methods in pharmacology. Academic, New YorkGoogle Scholar
  16. Vogel HG (2002) Drug discovery and evaluation pharmacological assays. Springer, BerlinCrossRefGoogle Scholar
  17. Woolley A (2008) A guide to practical toxicology. Informa Healthcare USA, New YorkCrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Jayanta Kumar Patra
    • 1
  • Swagat Kumar Das
    • 2
  • Gitishree Das
    • 3
  • Hrudayanath Thatoi
    • 4
  1. 1.Research Institute of Biotechnology & Medical Converged ScienceDongguk UniversityGoyang-siSouth Korea
  2. 2.Department of BiotechnologyCollege of Engineering and Technology, Biju Patnaik University of TechnologyOdishaIndia
  3. 3.Dongguk UniversityGoyang-siSouth Korea
  4. 4.Department of BiotechnologyNorth Orissa UniversityOdishaIndia

Personalised recommendations