Genotoxicity and Toxicological Studies

  • Jayanta Kumar Patra
  • Swagat Kumar Das
  • Gitishree Das
  • Hrudayanath Thatoi
Part of the Learning Materials in Biosciences book series (LMB)


Genotoxicity can be defined as the toxic changes on the genetic material (DNA, RNA) of the cell leading to destruction of nucleotide strand breakage. Genotoxins are the mutagens and cause genotoxicity by damaging chromosomal material causing mutation. Genotoxins includes both chemical substance and radiation. Genetic material damage in somatic cells may lead to malignancy whereas damage in germ cells may lead to heritable mutations causing various birth defects. Therefore, assessment of genotoxicity is important for evaluation of safety aspects of substances for protection of health and the environment. The results of the genotoxicity tests form the scientific basis for risk assessment and are used for classification and labelling of chemical substances.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Jayanta Kumar Patra
    • 1
  • Swagat Kumar Das
    • 2
  • Gitishree Das
    • 3
  • Hrudayanath Thatoi
    • 4
  1. 1.Research Institute of Biotechnology & Medical Converged ScienceDongguk UniversityGoyang-siSouth Korea
  2. 2.Department of BiotechnologyCollege of Engineering and Technology, Biju Patnaik University of TechnologyOdishaIndia
  3. 3.Dongguk UniversityGoyang-siSouth Korea
  4. 4.Department of BiotechnologyNorth Orissa UniversityOdishaIndia

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