Enhanced Biocompatibility via Adjusting the Soft-to-Hard Segment Ratios of Poly (Ether-Block-Amide) Medical Hollow Fiber Tube for Invasive Medical Devices
Poly(ether-block-amide) (Pebax) is a promising polymeric material for the application in biomedical area, which is significantly influenced by its property of biocompatibility. For segment copolymers like Pebax-family materials, the biocompatibility is closely related to the soft-to-hard segment ratios. This study aims to explore the relationship between the biocompatibility property and soft-to-hard segment ratios of Pebax medical hollow fiber tube for invasive medical devices. Various analytical techniques including Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), atomic force microscope (AFM), scanning electron microscopy (SEM) and dynamic thermomechanical analysis (DMA) were used to observe the Pebax hollow fiber tube with various soft-to-hard segment ratios. The results indicated that the degree of microphase separation increased with the decrease of the soft segment ratios of Pebax hollow fiber tube. Similarly, we have clearly observed the effect of soft-to-hard segment ratios in the wettability of Pebax films with the contact angle method. The biocompatibility of Pebax hollow fiber tube was characterized by hemolysis tests and vitro cytotoxicity tests. It was found that the biocompatibility was greatly influenced by the content of soft segment ratios. The satisfactory biocompatibility property can be achieved via reducing the soft segment ratios of Pebax hollow fiber tube.
This work was financially supported by the National Basic Research Program (2011 CB606101) of the China 973 Program, National Natural Science Foundation of China (No. 21404023), funding from State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University (No. LK1515).
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