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Molecular Diagnostics for Lung Cancer

  • Ashok KumarEmail author
  • Ashwani Tandon
Chapter

Abstract

Lung cancers are characterized by numerous genomic aberrations and some of them are sufficient to induce cell growth and impair the differentiation. These mutations are termed as driver mutations and include base substitutions, insertions, deletions, translocation and amplifications. With the advent of recent technologies these abnormalities can be detected precisely. There is paradigm shift in the diagnosis and current management of lung cancers from morphology to molecular analysis. Molecular characterization of lung cancers has allowed the identification of subsets of non-small lung cancers and provided new treatment targets which ultimately lead to more personalized or stratified targeted therapies. In this chapter, we discuss classification, common patho-genetic abnormalities and various methods for molecular diagnosis of lung cancers. We have also summarized emerging technologies for molecular diagnostics and the recommendations and expert consensus opinion according to current guidelines.

Keywords

Lung cancer NSCLC FISH qRT-PCR Next generation sequencing 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of BiochemistryAll India Institute of Medical SciencesBhopalIndia
  2. 2.Department of Pathology and Laboratory MedicineAll India Institute of Medical SciencesBhopalIndia

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