Emerging Trends in Flavonoid Research and Associated Toxicity
Flavonoids are highly diverse plant compounds that generally occur in a wide range of fruits, vegetables, nuts, and beverages. They are regularly consumed in the human diet and have various biological activities, including anti-inflammatory, anti-cancer, and anti-viral actions. Flavonoids may be one of the safest non-immunogenic drugs because they are small organic compounds that are normally absorbed by the human body over long periods of time. During the past few decades, there has been an increased flux of research activity on flavonoids, and many patents have been filed on flavonoids with therapeutic potential, with the number consistently showing an increasing trend.
Flavonoids are usually considered safe for consumption, but they also have side effects, e.g., upset stomach and headaches. Additionally, some preliminary evidence suggests that some flavonoids selected for study may generate byproducts that ultimately lead to loss of protein function in the body. Moreover, taking very high doses of some flavonoids may interfere with the functioning of the kidneys, or may cause changes in bacterial chromosomes, or may interfere with the body’s absorption of drugs, factors that ultimately decrease the activity of the immune system. This chapter summarizes the current research on the health effects of some flavonoids, and suggests possible expectations of their effects, as well as their different roles in cancer prevention versus treatment.
KeywordsFlavonoids Therapeutic potential Cancer Treatment Patents
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