Flavonoids as Emerging Anticancer Agents: Current Trends and Recent Advances in Phytotherapy

  • Dharambir Kashyap
  • Hardeep Singh Tuli
  • Mukerrem Betul Yerer
  • Anil K. Sharma
  • Harpal Singh Buttar
  • M. Youns
  • Javad Sharifi-Rad
  • Bahare Salehi
  • William N. Setzer


In recent years, the burden of several chronic diseases, including cancer, has increased rapidly worldwide. Although there are several diagnostic and treatment options available to health-care providers, the cancer-induced mortality rate is escalating globally. Interestingly enough, the development and utilization of plant-derived natural compounds therapy for the prevention and treatment of cancer are being rigorously pursued by overwhelming number of investigators. In the category of natural compounds, flavonoids occupy an important place and are being extensively studied in animal models and cancer patients to evaluate their anticancer potential. The chemopreventive role of flavonoids and their underlying mechanisms of action against cancer have been well documented in the literature. The present chapter summarizes the purported cellular, molecular, and genetic mechanisms of anticancer action of flavonoids, such as apoptosis induction, cell cycle arrest, anti-angiogenesis, anti-metastasis, and anti-inflammatory and antioxidant aspects. In addition, the anticancer roles of related flavonols (quercetin), flavones (luteolin), isoflavone (genistein), anthocyanidin (cyanidin), flavanone (naringenin), and flavan-3-ols (epigallocatechin-3-gallate) are also described.


Flavonoids Apoptosis Cell cycle arrest Anti-angiogenesis Anti-metastasis Synergistic effect Topoisomerase II miRNA 



The authors would like to acknowledge the assistance of Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, and Maharishi Markandeshwar (deemed to be university), Mullana, Ambala, Haryana, for providing the required facilities to complete this study.

Conflict of Interest

There exists no conflict of interest amongst authors regarding the publication of this book chapter.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Dharambir Kashyap
    • 1
  • Hardeep Singh Tuli
    • 2
  • Mukerrem Betul Yerer
    • 3
  • Anil K. Sharma
    • 2
  • Harpal Singh Buttar
    • 4
  • M. Youns
    • 5
  • Javad Sharifi-Rad
    • 6
  • Bahare Salehi
    • 7
  • William N. Setzer
    • 8
  1. 1.Department of HistopathologyPostgraduate Institute of Medical Education and Research (PGIMER)ChandigarhIndia
  2. 2.Department of BiotechnologyMaharishi Markandeshwar (Deemed to be University)Mullana-AmbalaIndia
  3. 3.Department of Pharmacology, Faculty of PharmacyUniversity of ErciyesKayseriTurkey
  4. 4.Department of Pathology and Laboratory Medicine, Faculty of MedicineUniversity of OttawaOttawaCanada
  5. 5.Department of Biochemistry and Molecular biologyHelwan UniversityHelwanEgypt
  6. 6.Food Safety Research Center (salt)Semnan University of Medical SciencesSemnanIran
  7. 7.Student Research Committee, School of MedicineBam University of Medical SciencesBamIran
  8. 8.Department of ChemistryUniversity of Alabama in HuntsvilleHuntsvilleUSA

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