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Applications of Polyhydroxyalkanoates Based Nanovehicles as Drug Carriers

  • Mohanasundaram Sugappriya
  • Dorairaj Sudarsanam
  • Jerrine Joseph
  • Mudasir A. Mir
  • Chandrabose Selvaraj
Chapter

Abstract

Polyhydroxyalkanoates (PHAs) are the biodegradable polyesters synthesized from the bacterial origin with high therapeutic importance due to their major biopolymer properties like biodegradability, biocompatibility, non-toxicity and thermo-plasticity. These hypotheses make the PHAs as one of the drug carrier or nanovehicles for therapeutic drug delivery. Drug delivery is one of the emerging fields in biological science, which gives application of delivering the promising drug molecules in the desired drug target, with increasing dissolution rate and bioavailability. Understanding the drug-polymer interactions and controlled release makes the combo of the perfect drug molecule and the biopolymer, and in this, the PHA is reported to be a better natural origin drug carrier. Several reports suggest that, chemical entities of PHA show enhanced activity and used as one of the promising nanocarrier. Experimental test by several assays shows PHA’s as one of the compatible biopolymers in tissues. This chapter comes up with various applications related to PHAs like medical implants, adhesion barriers, drug carriers, tissue engineering, Nano based targeted delivery. Overall, this chapter will provide a perfect base for studies on PHA related to drug carrier studies.

Keywords

Biopolymer Polyhydroxyalkanotes Carriers Nanovehicles Implants Scaffolds Suture Cancer Wound healing Bioplastics Drug delivery 

Abbreviations

APTS

para-toluene sulfonic acid monohydrate

DTXL

Docetaxel

HA

hydroxyapatite

HDI

1,6-hexamethylene di-isocyanate

P3

poly(esterurethane)s

P3HB4HB

poly(R-3-hydroxybutyrate-co-4-hydroxybutyrate)

P4HB

poly-4-hydroxybutyrate;

PHA(s)

Polyhydroxyalkanoate(s)

PhaP

amphiphilic PHA granule binding protein

PhaR

PHA synthesis repressor protein

PHB

poly-(R)-3-hydroxybutyrate;

PHB

Polyhydroxybutyrate

PHBHHx

poly(R-3-hydroxybutyrate-co-R-3-hydroxyhexanoate)

PHBHx

Poly(hydroxybutyrate-co-hydroxyhexanoate)

PHBO

Poly(hydroxybutyrate-co-hydroxyoctanoate)

PHBV

Poly(hydroxybutyrate-co-hydroxyvalerate)

PHBV

poly(R-3-hydroxybutyrate-co-R-3-hydroxyvalerate)

PHBVHHx

poly(R-3-hydroxy-butyrate-co-R-3-hydroxyvalerate-co-R-3-hydroxyhexanoate)

PHHx

Poly(hydroxyhexanoate)

PHHx

Poly(hydroxyhexanoate)

PHO

Poly(hydroxyoctanoate)

PHO

poly-(R)-3-hydroxyoctanoate;

PPC

Poly propylene carbonate

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Mohanasundaram Sugappriya
    • 1
  • Dorairaj Sudarsanam
    • 2
  • Jerrine Joseph
    • 3
  • Mudasir A. Mir
    • 4
  • Chandrabose Selvaraj
    • 5
  1. 1.Research and Development CentreBharathiar UniversityCoimbatoreIndia
  2. 2.Department of Zoology and Advanced BiotechnologyLoyola CollegeChennaiIndia
  3. 3.Centre for Drug Discovery and Development, Jeppiaar Research ParkSathyabama Deemed to be UniversityChennaiIndia
  4. 4.Centre for Plant Biotechnology, Division of BiotechnologySher-e-Kashmir University of Agricultural Sciences and Technology of KashmirShalimarIndia
  5. 5.School of Basic ScienceIndian Institute of Technology MandiKamandIndia

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